Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models
One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously r...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3432701 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565349808078848 |
|---|---|
| author | D. Betty Lew Christie F. Michael Tracie Overbeck W. Scout Robinson Erin L. Rohman Jeffrey M. Lehman Jennifer K. Patel Brandi Eiseman Kim S. LeMessurier Amali E. Samarasinghe M. Waleed Gaber |
| author_facet | D. Betty Lew Christie F. Michael Tracie Overbeck W. Scout Robinson Erin L. Rohman Jeffrey M. Lehman Jennifer K. Patel Brandi Eiseman Kim S. LeMessurier Amali E. Samarasinghe M. Waleed Gaber |
| author_sort | D. Betty Lew |
| collection | DOAJ |
| description | One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously reported that ASM cells express a mannose receptor (ASM-MR) and that mannan derived from Saccharomyces cerevisiae (SC-MN) inhibits mannosyl-rich lysosomal hydrolase-induced bovine ASM cell proliferation. Using a humanized transgenic mouse strain (huASM-MRC2) expressing the human MRC2 receptor in a SM tissue-specific manner, we have demonstrated that ASM hyperplasia/hypertrophy can occur as early as 15 days after allergen challenge in this mouse model and this phenomenon is preventable with SC-MN treatment. This proof-of-concept study would facilitate future development of a potential asthma therapeutic agent with dual function of anti-inflammatory and anti-smooth muscle remodeling effects. |
| format | Article |
| id | doaj-art-051df313f10c41328f2b06ffb029af45 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-051df313f10c41328f2b06ffb029af452025-02-03T01:07:53ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/34327013432701Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse ModelsD. Betty Lew0Christie F. Michael1Tracie Overbeck2W. Scout Robinson3Erin L. Rohman4Jeffrey M. Lehman5Jennifer K. Patel6Brandi Eiseman7Kim S. LeMessurier8Amali E. Samarasinghe9M. Waleed Gaber10Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USADepartment of Pediatrics and Hematology-Oncology, Baylor College of Medicine and Texas Children’s Cancer Center, Houston, TX, USAOne of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously reported that ASM cells express a mannose receptor (ASM-MR) and that mannan derived from Saccharomyces cerevisiae (SC-MN) inhibits mannosyl-rich lysosomal hydrolase-induced bovine ASM cell proliferation. Using a humanized transgenic mouse strain (huASM-MRC2) expressing the human MRC2 receptor in a SM tissue-specific manner, we have demonstrated that ASM hyperplasia/hypertrophy can occur as early as 15 days after allergen challenge in this mouse model and this phenomenon is preventable with SC-MN treatment. This proof-of-concept study would facilitate future development of a potential asthma therapeutic agent with dual function of anti-inflammatory and anti-smooth muscle remodeling effects.http://dx.doi.org/10.1155/2017/3432701 |
| spellingShingle | D. Betty Lew Christie F. Michael Tracie Overbeck W. Scout Robinson Erin L. Rohman Jeffrey M. Lehman Jennifer K. Patel Brandi Eiseman Kim S. LeMessurier Amali E. Samarasinghe M. Waleed Gaber Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models Journal of Immunology Research |
| title | Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models |
| title_full | Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models |
| title_fullStr | Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models |
| title_full_unstemmed | Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models |
| title_short | Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models |
| title_sort | beneficial effects of prebiotic saccharomyces cerevisiae mannan on allergic asthma mouse models |
| url | http://dx.doi.org/10.1155/2017/3432701 |
| work_keys_str_mv | AT dbettylew beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT christiefmichael beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT tracieoverbeck beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT wscoutrobinson beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT erinlrohman beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT jeffreymlehman beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT jenniferkpatel beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT brandieiseman beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT kimslemessurier beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT amaliesamarasinghe beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels AT mwaleedgaber beneficialeffectsofprebioticsaccharomycescerevisiaemannanonallergicasthmamousemodels |