An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation
Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/235460 |
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| author | Silvia Sedda Irene Marafini Michele M. Figliuzzi Francesco Pallone Giovanni Monteleone |
| author_facet | Silvia Sedda Irene Marafini Michele M. Figliuzzi Francesco Pallone Giovanni Monteleone |
| author_sort | Silvia Sedda |
| collection | DOAJ |
| description | Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of phenotypic and functional criteria and termed ILCs1, ILCs2, and ILCs3. Specifically, ILCs1 express the transcription factor T-bet and secrete T helper type-1- (Th1-) related cytokines, ILCs2 are dependent on the transcription factor RORα and express Gata-3 and the chemokine receptor homologous molecule (CRTH2) and produce Th2-related cytokines, and ILCs3 express the transcription factor RORγt and synthesize interleukin- (IL-) 17, IL-22, and, under specific stimuli, interferon-γ. ILCs represent a relatively small population in the gut, but accumulating evidence suggests that these cells could play a decisive role in orchestrating both protective and detrimental immune responses. In this review, we will summarize the present knowledge on the distribution of ILCs in the intestinal mucosa, with particular focus on their role in the control of both infections and effector cytokine response in immune-mediated pathologies. |
| format | Article |
| id | doaj-art-05136bb050ff4d0d849ce8c87b0b4fe4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-05136bb050ff4d0d849ce8c87b0b4fe42025-02-03T05:52:18ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/235460235460An Overview of the Role of Innate Lymphoid Cells in Gut Infections and InflammationSilvia Sedda0Irene Marafini1Michele M. Figliuzzi2Francesco Pallone3Giovanni Monteleone4Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyInnate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of phenotypic and functional criteria and termed ILCs1, ILCs2, and ILCs3. Specifically, ILCs1 express the transcription factor T-bet and secrete T helper type-1- (Th1-) related cytokines, ILCs2 are dependent on the transcription factor RORα and express Gata-3 and the chemokine receptor homologous molecule (CRTH2) and produce Th2-related cytokines, and ILCs3 express the transcription factor RORγt and synthesize interleukin- (IL-) 17, IL-22, and, under specific stimuli, interferon-γ. ILCs represent a relatively small population in the gut, but accumulating evidence suggests that these cells could play a decisive role in orchestrating both protective and detrimental immune responses. In this review, we will summarize the present knowledge on the distribution of ILCs in the intestinal mucosa, with particular focus on their role in the control of both infections and effector cytokine response in immune-mediated pathologies.http://dx.doi.org/10.1155/2014/235460 |
| spellingShingle | Silvia Sedda Irene Marafini Michele M. Figliuzzi Francesco Pallone Giovanni Monteleone An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation Mediators of Inflammation |
| title | An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation |
| title_full | An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation |
| title_fullStr | An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation |
| title_full_unstemmed | An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation |
| title_short | An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation |
| title_sort | overview of the role of innate lymphoid cells in gut infections and inflammation |
| url | http://dx.doi.org/10.1155/2014/235460 |
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