Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolip...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/248135 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554334518247424 |
|---|---|
| author | Simon A. Young John G. Mina Paul W. Denny Terry K. Smith |
| author_facet | Simon A. Young John G. Mina Paul W. Denny Terry K. Smith |
| author_sort | Simon A. Young |
| collection | DOAJ |
| description | Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer's disease, and numerous important human pathogens. In this paper we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions. |
| format | Article |
| id | doaj-art-0507709fddc440fea2da4b0dab5db736 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-0507709fddc440fea2da4b0dab5db7362025-02-03T05:51:48ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/248135248135Sphingolipid and Ceramide Homeostasis: Potential Therapeutic TargetsSimon A. Young0John G. Mina1Paul W. Denny2Terry K. Smith3School of Biology and Chemistry, Biomedical Sciences Research Complex, University of St Andrews, North Haugh, KY16 9ST, UKBiophysical Sciences Institute, School of Biological and Biomedical Sciences and Department of Chemistry, University of Durham University Science Laboratories, South Road, Durham DH1 3LE, UKBiophysical Sciences Institute, School of Biological and Biomedical Sciences and Department of Chemistry, University of Durham University Science Laboratories, South Road, Durham DH1 3LE, UKSchool of Biology and Chemistry, Biomedical Sciences Research Complex, University of St Andrews, North Haugh, KY16 9ST, UKSphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer's disease, and numerous important human pathogens. In this paper we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions.http://dx.doi.org/10.1155/2012/248135 |
| spellingShingle | Simon A. Young John G. Mina Paul W. Denny Terry K. Smith Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets Biochemistry Research International |
| title | Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets |
| title_full | Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets |
| title_fullStr | Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets |
| title_full_unstemmed | Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets |
| title_short | Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets |
| title_sort | sphingolipid and ceramide homeostasis potential therapeutic targets |
| url | http://dx.doi.org/10.1155/2012/248135 |
| work_keys_str_mv | AT simonayoung sphingolipidandceramidehomeostasispotentialtherapeutictargets AT johngmina sphingolipidandceramidehomeostasispotentialtherapeutictargets AT paulwdenny sphingolipidandceramidehomeostasispotentialtherapeutictargets AT terryksmith sphingolipidandceramidehomeostasispotentialtherapeutictargets |