Results of Gamma Knife Radiosurgery in Acromegaly
Objective. Single-session radiosurgery with Gamma Knife (GK) may be a potential adjuvant treatment in acromegaly. We analyzed the safety and efficacy of GK in patients who had previously received maximal surgical debulking at our hospital. Methods. The study was a retrospective analysis of hormonal,...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/342034 |
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| _version_ | 1832564101369298944 |
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| author | Alberto Franzin Giorgio Spatola Marco Losa Piero Picozzi Pietro Mortini |
| author_facet | Alberto Franzin Giorgio Spatola Marco Losa Piero Picozzi Pietro Mortini |
| author_sort | Alberto Franzin |
| collection | DOAJ |
| description | Objective. Single-session radiosurgery with Gamma Knife (GK) may be a potential adjuvant treatment in acromegaly. We analyzed the safety and efficacy of GK in patients who had previously received maximal surgical debulking at our hospital. Methods. The study was a retrospective analysis of hormonal, radiological, and ophthalmologic data collected in a predefined protocol from 1994 to 2009. The mean age at treatment was 42.3 years (range 22–67 yy). 103 acromegalic patients participated in the study. The median follow-up was 71 months (IQ range 43–107). All patients were treated with GK for residual or recurrent GH-secreting adenoma. Results. Sixty-three patients (61.2%) reached the main outcome of the study. The rate of remission was 58.3% at 5 years (95% CI 47.6–69.0%). Other 15 patients (14.6%) were in remission after GK while on treatment with somatostatin analogues. No serious side effects occurred after GK. Eight patients (7.8%) experienced a new deficit of pituitary function. New cases of hypogonadism, hypothyroidism, and hypoadrenalism occurred in 4 of 77 patients (5.2%), 3 of 95 patients (3.2%), and 6 of 100 patients at risk (6.0%), respectively. Conclusion. In a highly selected group of acromegalic patients, GK treatment had good efficacy and safety. |
| format | Article |
| id | doaj-art-04f9f623648d4338ba00de8b3f1adc28 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-04f9f623648d4338ba00de8b3f1adc282025-02-03T01:11:47ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/342034342034Results of Gamma Knife Radiosurgery in AcromegalyAlberto Franzin0Giorgio Spatola1Marco Losa2Piero Picozzi3Pietro Mortini4Department of Neurosurgery and Radiosurgery, Division of Neuroscience, IRCCS San Raffaele, 20132 Milan, ItalyDepartment of Neurosurgery and Radiosurgery, Division of Neuroscience, IRCCS San Raffaele, 20132 Milan, ItalyDepartment of Neurosurgery and Radiosurgery, Division of Neuroscience, IRCCS San Raffaele, 20132 Milan, ItalyDepartment of Neurosurgery and Radiosurgery, Division of Neuroscience, IRCCS San Raffaele, 20132 Milan, ItalyDepartment of Neurosurgery and Radiosurgery, Division of Neuroscience, IRCCS San Raffaele, 20132 Milan, ItalyObjective. Single-session radiosurgery with Gamma Knife (GK) may be a potential adjuvant treatment in acromegaly. We analyzed the safety and efficacy of GK in patients who had previously received maximal surgical debulking at our hospital. Methods. The study was a retrospective analysis of hormonal, radiological, and ophthalmologic data collected in a predefined protocol from 1994 to 2009. The mean age at treatment was 42.3 years (range 22–67 yy). 103 acromegalic patients participated in the study. The median follow-up was 71 months (IQ range 43–107). All patients were treated with GK for residual or recurrent GH-secreting adenoma. Results. Sixty-three patients (61.2%) reached the main outcome of the study. The rate of remission was 58.3% at 5 years (95% CI 47.6–69.0%). Other 15 patients (14.6%) were in remission after GK while on treatment with somatostatin analogues. No serious side effects occurred after GK. Eight patients (7.8%) experienced a new deficit of pituitary function. New cases of hypogonadism, hypothyroidism, and hypoadrenalism occurred in 4 of 77 patients (5.2%), 3 of 95 patients (3.2%), and 6 of 100 patients at risk (6.0%), respectively. Conclusion. In a highly selected group of acromegalic patients, GK treatment had good efficacy and safety.http://dx.doi.org/10.1155/2012/342034 |
| spellingShingle | Alberto Franzin Giorgio Spatola Marco Losa Piero Picozzi Pietro Mortini Results of Gamma Knife Radiosurgery in Acromegaly International Journal of Endocrinology |
| title | Results of Gamma Knife Radiosurgery in Acromegaly |
| title_full | Results of Gamma Knife Radiosurgery in Acromegaly |
| title_fullStr | Results of Gamma Knife Radiosurgery in Acromegaly |
| title_full_unstemmed | Results of Gamma Knife Radiosurgery in Acromegaly |
| title_short | Results of Gamma Knife Radiosurgery in Acromegaly |
| title_sort | results of gamma knife radiosurgery in acromegaly |
| url | http://dx.doi.org/10.1155/2012/342034 |
| work_keys_str_mv | AT albertofranzin resultsofgammakniferadiosurgeryinacromegaly AT giorgiospatola resultsofgammakniferadiosurgeryinacromegaly AT marcolosa resultsofgammakniferadiosurgeryinacromegaly AT pieropicozzi resultsofgammakniferadiosurgeryinacromegaly AT pietromortini resultsofgammakniferadiosurgeryinacromegaly |