Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats
The present study evaluates the effects of short term (15 days) exposure of low dose (300 μg kg−1) of atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) on antioxidant status and markers of liver and kidney damage in normal (nondiabetic) and diabetic male Wistar rats. Rats were divided...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2014/536759 |
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| author | Dinesh Babu Jestadi Alugoju Phaniendra Undru Babji Thupakula Srinu Bhavatharini Shanmuganathan Latha Periyasamy |
| author_facet | Dinesh Babu Jestadi Alugoju Phaniendra Undru Babji Thupakula Srinu Bhavatharini Shanmuganathan Latha Periyasamy |
| author_sort | Dinesh Babu Jestadi |
| collection | DOAJ |
| description | The present study evaluates the effects of short term (15 days) exposure of low dose (300 μg kg−1) of atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) on antioxidant status and markers of liver and kidney damage in normal (nondiabetic) and diabetic male Wistar rats. Rats were divided into four groups: Group I as normal control, Group II as atrazine treated, Group III as diabetic control, and Group IV as atrazine treated diabetic rats. Atrazine administration resulted in increased MDA concentration as well as increased activities of SOD, CAT, and GPx in both liver and kidney of atrazine treated and atrazine treated diabetic rats. However, GSH level was decreased in both liver and kidney of atrazine treated and atrazine treated diabetic rats. Atrazine administration led to significant increase in liver damage biomarkers such as AST, ALT, and ALP as well as kidney damage biomarkers such as creatinine and urea in both normal and diabetic rats, but this increase was more pronounced in diabetic rats when compared to normal rats. In conclusion, the results of the present study demonstrate that short term exposure of atrazine at a dose of 300 μg kg−1 could potentially induce oxidative damage in liver and kidney of both normal and diabetic rats. |
| format | Article |
| id | doaj-art-04f7843b226b4ce1947eaa76a58013f9 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-04f7843b226b4ce1947eaa76a58013f92025-02-03T01:11:47ZengWileyJournal of Toxicology1687-81911687-82052014-01-01201410.1155/2014/536759536759Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic RatsDinesh Babu Jestadi0Alugoju Phaniendra1Undru Babji2Thupakula Srinu3Bhavatharini Shanmuganathan4Latha Periyasamy5Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaThe present study evaluates the effects of short term (15 days) exposure of low dose (300 μg kg−1) of atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) on antioxidant status and markers of liver and kidney damage in normal (nondiabetic) and diabetic male Wistar rats. Rats were divided into four groups: Group I as normal control, Group II as atrazine treated, Group III as diabetic control, and Group IV as atrazine treated diabetic rats. Atrazine administration resulted in increased MDA concentration as well as increased activities of SOD, CAT, and GPx in both liver and kidney of atrazine treated and atrazine treated diabetic rats. However, GSH level was decreased in both liver and kidney of atrazine treated and atrazine treated diabetic rats. Atrazine administration led to significant increase in liver damage biomarkers such as AST, ALT, and ALP as well as kidney damage biomarkers such as creatinine and urea in both normal and diabetic rats, but this increase was more pronounced in diabetic rats when compared to normal rats. In conclusion, the results of the present study demonstrate that short term exposure of atrazine at a dose of 300 μg kg−1 could potentially induce oxidative damage in liver and kidney of both normal and diabetic rats.http://dx.doi.org/10.1155/2014/536759 |
| spellingShingle | Dinesh Babu Jestadi Alugoju Phaniendra Undru Babji Thupakula Srinu Bhavatharini Shanmuganathan Latha Periyasamy Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats Journal of Toxicology |
| title | Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats |
| title_full | Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats |
| title_fullStr | Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats |
| title_full_unstemmed | Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats |
| title_short | Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats |
| title_sort | effects of short term exposure of atrazine on the liver and kidney of normal and diabetic rats |
| url | http://dx.doi.org/10.1155/2014/536759 |
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