Injection of Botulinum Toxin a to Upper Esophageal Sphincter for Oropharyngeal Dysphagia in Two Patients with Inclusion Body Myositis
Inclusion body myositis (IBM) is a progressive degenerative skeletal muscle disease leading to weakening and atrophy of both proximal and distal muscles. Dysphagia is reported in up to 86% of IBM patients. Surgical cricopharyngeal myotomy may be effective for cricopharyngeal dysphagia and there is o...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2004/360537 |
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| author | Louis WC Liu Mark Tarnopolsky David Armstrong |
| author_facet | Louis WC Liu Mark Tarnopolsky David Armstrong |
| author_sort | Louis WC Liu |
| collection | DOAJ |
| description | Inclusion body myositis (IBM) is a progressive degenerative skeletal muscle disease leading to weakening and atrophy of both proximal and distal muscles. Dysphagia is reported in up to 86% of IBM patients. Surgical cricopharyngeal myotomy may be effective for cricopharyngeal dysphagia and there is one published report that botulinum toxin A, injected into the cricopharyngeus muscle using a hypopharyngoscope under general anesthesia, relieved IBM-associated dysphagia. This report presents the first documentation of botulinum toxin A injection into the upper esophageal sphincter using a flexible esophagogastroduodenoscope under conscious sedation, to reduce upper esophageal sphincter pressure and successfully alleviate oropharyngeal dysphagia in two IBM patients. |
| format | Article |
| id | doaj-art-04f5ee7d20654a16bf66f660967f7730 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-04f5ee7d20654a16bf66f660967f77302025-02-03T01:25:53ZengWileyCanadian Journal of Gastroenterology0835-79002004-01-0118639739910.1155/2004/360537Injection of Botulinum Toxin a to Upper Esophageal Sphincter for Oropharyngeal Dysphagia in Two Patients with Inclusion Body MyositisLouis WC Liu0Mark Tarnopolsky1David Armstrong2Hamilton Health Sciences, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, CanadaDivision of Neurology and Rehabilitation, McMaster University Medical Centre, Hamilton, Ontario, CanadaHamilton Health Sciences, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, CanadaInclusion body myositis (IBM) is a progressive degenerative skeletal muscle disease leading to weakening and atrophy of both proximal and distal muscles. Dysphagia is reported in up to 86% of IBM patients. Surgical cricopharyngeal myotomy may be effective for cricopharyngeal dysphagia and there is one published report that botulinum toxin A, injected into the cricopharyngeus muscle using a hypopharyngoscope under general anesthesia, relieved IBM-associated dysphagia. This report presents the first documentation of botulinum toxin A injection into the upper esophageal sphincter using a flexible esophagogastroduodenoscope under conscious sedation, to reduce upper esophageal sphincter pressure and successfully alleviate oropharyngeal dysphagia in two IBM patients.http://dx.doi.org/10.1155/2004/360537 |
| spellingShingle | Louis WC Liu Mark Tarnopolsky David Armstrong Injection of Botulinum Toxin a to Upper Esophageal Sphincter for Oropharyngeal Dysphagia in Two Patients with Inclusion Body Myositis Canadian Journal of Gastroenterology |
| title | Injection of Botulinum Toxin a to Upper Esophageal Sphincter for Oropharyngeal Dysphagia in Two Patients with Inclusion Body Myositis |
| title_full | Injection of Botulinum Toxin a to Upper Esophageal Sphincter for Oropharyngeal Dysphagia in Two Patients with Inclusion Body Myositis |
| title_fullStr | Injection of Botulinum Toxin a to Upper Esophageal Sphincter for Oropharyngeal Dysphagia in Two Patients with Inclusion Body Myositis |
| title_full_unstemmed | Injection of Botulinum Toxin a to Upper Esophageal Sphincter for Oropharyngeal Dysphagia in Two Patients with Inclusion Body Myositis |
| title_short | Injection of Botulinum Toxin a to Upper Esophageal Sphincter for Oropharyngeal Dysphagia in Two Patients with Inclusion Body Myositis |
| title_sort | injection of botulinum toxin a to upper esophageal sphincter for oropharyngeal dysphagia in two patients with inclusion body myositis |
| url | http://dx.doi.org/10.1155/2004/360537 |
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