Dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift
Abstract The study aims to evaluate the levels of nitrosamine, a known carcinogenic compound, in processed meat products and to assess its dietary intake and margin of exposure among medical staff, including physicians, pharmacists, and nurses working night shifts at Alexandria University Hospitals....
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-84059-y |
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| author | Dalia Ibrahim Tayel Noorhan K. Farrag Samar Mohamed Aborhyem |
| author_facet | Dalia Ibrahim Tayel Noorhan K. Farrag Samar Mohamed Aborhyem |
| author_sort | Dalia Ibrahim Tayel |
| collection | DOAJ |
| description | Abstract The study aims to evaluate the levels of nitrosamine, a known carcinogenic compound, in processed meat products and to assess its dietary intake and margin of exposure among medical staff, including physicians, pharmacists, and nurses working night shifts at Alexandria University Hospitals. Additionally, the study seeks to evaluate the participants’ knowledge of dietary sources and regulatory limits of carcinogens. A cross-sectional study was conducted with 420 participants. Results showed that hotdogs contained the highest nitrosamine levels (159.24 ± 87.99 µg/g) with a consumption pattern of 0.02126 µg/kg BW/day. In contrast, sausages and burgers had the lowest nitrosamine content (2.36 µg/g and 2.37 µg/g, respectively). Luncheon meat also exhibited low nitrosamine levels and consumption patterns, at 18.53 µg/g and 0.00141 µg/kg BW/day, respectively. The Margin of Exposure (MOE) was calculated to assess risk, with a Benchmark Dose Lower Confidence Limit (BMDL)10 value of 29 µg/kg BW/day as the reference point. MOE values ≥ 17,000, derived for nitrosamine exposure in this study, indicate a low level of concern for carcinogenic risk. A statistically significant difference in dietary nitrosamine intake was observed across different professions among the medical staff (p < 0.001). |
| format | Article |
| id | doaj-art-04e65daceba240beb5bd789ad062f92e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-04e65daceba240beb5bd789ad062f92e2025-01-19T12:22:50ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-024-84059-yDietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shiftDalia Ibrahim Tayel0Noorhan K. Farrag1Samar Mohamed Aborhyem2Nutrition Department, High Institute of Public Health, Alexandria UniversityNutrition Department, High Institute of Public Health, Alexandria UniversityNutrition Department, High Institute of Public Health, Alexandria UniversityAbstract The study aims to evaluate the levels of nitrosamine, a known carcinogenic compound, in processed meat products and to assess its dietary intake and margin of exposure among medical staff, including physicians, pharmacists, and nurses working night shifts at Alexandria University Hospitals. Additionally, the study seeks to evaluate the participants’ knowledge of dietary sources and regulatory limits of carcinogens. A cross-sectional study was conducted with 420 participants. Results showed that hotdogs contained the highest nitrosamine levels (159.24 ± 87.99 µg/g) with a consumption pattern of 0.02126 µg/kg BW/day. In contrast, sausages and burgers had the lowest nitrosamine content (2.36 µg/g and 2.37 µg/g, respectively). Luncheon meat also exhibited low nitrosamine levels and consumption patterns, at 18.53 µg/g and 0.00141 µg/kg BW/day, respectively. The Margin of Exposure (MOE) was calculated to assess risk, with a Benchmark Dose Lower Confidence Limit (BMDL)10 value of 29 µg/kg BW/day as the reference point. MOE values ≥ 17,000, derived for nitrosamine exposure in this study, indicate a low level of concern for carcinogenic risk. A statistically significant difference in dietary nitrosamine intake was observed across different professions among the medical staff (p < 0.001).https://doi.org/10.1038/s41598-024-84059-yDietary intakeRisk assessmentMargin of exposureNitrosamineMedical staffNight shift |
| spellingShingle | Dalia Ibrahim Tayel Noorhan K. Farrag Samar Mohamed Aborhyem Dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift Scientific Reports Dietary intake Risk assessment Margin of exposure Nitrosamine Medical staff Night shift |
| title | Dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift |
| title_full | Dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift |
| title_fullStr | Dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift |
| title_full_unstemmed | Dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift |
| title_short | Dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift |
| title_sort | dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift |
| topic | Dietary intake Risk assessment Margin of exposure Nitrosamine Medical staff Night shift |
| url | https://doi.org/10.1038/s41598-024-84059-y |
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