Bladder Dysfunction and Vesicoureteral Reflux

In this overview the influence of functional bladder disturbances and of its treatment on the resolution of vesicoureteral reflux (VUR) in children is discussed. Historically both bladder dysfunction entities, the overactive bladder (OAB) and the dysfunctional voiding (DV), have been described in co...

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Main Author: Ulla Sillén
Format: Article
Language:English
Published: Wiley 2008-01-01
Series:Advances in Urology
Online Access:http://dx.doi.org/10.1155/2008/815472
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author Ulla Sillén
author_facet Ulla Sillén
author_sort Ulla Sillén
collection DOAJ
description In this overview the influence of functional bladder disturbances and of its treatment on the resolution of vesicoureteral reflux (VUR) in children is discussed. Historically both bladder dysfunction entities, the overactive bladder (OAB) and the dysfunctional voiding (DV), have been described in conjunction with VUR. Treatment of the dysfunction was also considered to influence spontaneous resolution in a positive way. During the last decades, however, papers have been published which could not support these results. Regarding the OAB, a prospective study with treatment of the bladder overactivity with anticholinergics, did not influence spontaneous resolution rate in children with a dysfunction including also the voiding phase, DV and DES (dysfunctional elimination syndrome), most studies indicate a negative influence on the resolution rate of VUR in children, both before and after the age for bladder control, both with and without treatment. However, a couple of uncontrolled studies indicate that there is a high short-term resolution rate after treatment with flow biofeedback. It should be emphasized that the voiding phase dysfunctions (DV and DES) are more severe than the genuine filling phase dysfunction (OAB), with an increased frequency of UTI and renal damage in the former groups. To be able to answer the question if treatment of bladder dysfunction influence the resolution rate of VUR in children, randomized controlled studies must be performed.
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spelling doaj-art-04d3719400a84d3dbf9b936f891226ae2025-02-03T01:13:07ZengWileyAdvances in Urology1687-63691687-63772008-01-01200810.1155/2008/815472815472Bladder Dysfunction and Vesicoureteral RefluxUlla Sillén0Pediatric Uronephrologic Center (PUNC), Queen Silvia Children's Hospital, The Sahlgrenska Academy at University of Gothenburg, 416 85 Gothenburg, SwedenIn this overview the influence of functional bladder disturbances and of its treatment on the resolution of vesicoureteral reflux (VUR) in children is discussed. Historically both bladder dysfunction entities, the overactive bladder (OAB) and the dysfunctional voiding (DV), have been described in conjunction with VUR. Treatment of the dysfunction was also considered to influence spontaneous resolution in a positive way. During the last decades, however, papers have been published which could not support these results. Regarding the OAB, a prospective study with treatment of the bladder overactivity with anticholinergics, did not influence spontaneous resolution rate in children with a dysfunction including also the voiding phase, DV and DES (dysfunctional elimination syndrome), most studies indicate a negative influence on the resolution rate of VUR in children, both before and after the age for bladder control, both with and without treatment. However, a couple of uncontrolled studies indicate that there is a high short-term resolution rate after treatment with flow biofeedback. It should be emphasized that the voiding phase dysfunctions (DV and DES) are more severe than the genuine filling phase dysfunction (OAB), with an increased frequency of UTI and renal damage in the former groups. To be able to answer the question if treatment of bladder dysfunction influence the resolution rate of VUR in children, randomized controlled studies must be performed.http://dx.doi.org/10.1155/2008/815472
spellingShingle Ulla Sillén
Bladder Dysfunction and Vesicoureteral Reflux
Advances in Urology
title Bladder Dysfunction and Vesicoureteral Reflux
title_full Bladder Dysfunction and Vesicoureteral Reflux
title_fullStr Bladder Dysfunction and Vesicoureteral Reflux
title_full_unstemmed Bladder Dysfunction and Vesicoureteral Reflux
title_short Bladder Dysfunction and Vesicoureteral Reflux
title_sort bladder dysfunction and vesicoureteral reflux
url http://dx.doi.org/10.1155/2008/815472
work_keys_str_mv AT ullasillen bladderdysfunctionandvesicoureteralreflux