A comparison of frequentist and Bayesian approaches to the Personalised Randomised Controlled Trial (PRACTical)—design and analysis considerations

A comparison of frequentist and Bayesian approaches to the Personalised Randomised Controlled Trial (PRACTical)—design and analysis considerations

Abstract Background Multiple treatment options frequently exist for a single medical condition with no single standard of care (SoC), rendering a classic randomised trial comparing a specific treatment to a control treatment infeasible. A novel design, the personalised randomised controlled trial (P...

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Bibliographic Details
Main Authors: Holly Jackson, Yiyun Shou, Nur Amira Binte Mohamed Azad, Jing Wen Chua, Rebecca Lynn Perez, Xinru Wang, Marlieke E. A. de Kraker, Yin Mo
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medical Research Methodology
Subjects:
PRACTical
Bayesian
Statistical simulation
Personalised randomisation
Trial design
Infectious diseases
Online Access:https://doi.org/10.1186/s12874-025-02537-x
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