Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants
We conducted a retrospective case series study to evaluate the safety of fosfluconazole prophylaxis for preventing invasive fungal infection in VLBW infants with a central vascular access. Fosfluconazole was administered intravenously at a dose of 6 mg/kg everyday during which time a central venous...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2009/274768 |
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| author | Daijiro Takahashi Tomohiko Nakamura Reiko Shigematsu Miyu Matsui Shunsuke Araki Kazuyasu Kubo Hiroshi Sato Akira Shirahata |
| author_facet | Daijiro Takahashi Tomohiko Nakamura Reiko Shigematsu Miyu Matsui Shunsuke Araki Kazuyasu Kubo Hiroshi Sato Akira Shirahata |
| author_sort | Daijiro Takahashi |
| collection | DOAJ |
| description | We conducted a retrospective case series study to evaluate the safety of fosfluconazole prophylaxis for preventing invasive fungal infection in VLBW infants with a central vascular access. Fosfluconazole was administered intravenously at a dose of 6 mg/kg everyday during which time a central venous catheter was placed. A total of 23 infants met the criteria for enrollment in our study. No cases of fungal infection were detected during the central venous catheter placement in the group. None of the infants had an elevated β-D-glucan, and all of them were still alive at discharge. Regarding the liver and renal function, no statistically significant differences were observed before and at the end of fosfluconazole prophylaxis. The results of this study demonstrate that fosfluconazole prophylaxis in preventing invasive fungal infection was well tolerated by VLBW infants. This is a first report to describe antifungal prophylaxis using fosfluconazole for VLBW infants. |
| format | Article |
| id | doaj-art-04c91866a5e7480687fd58bf694b68a5 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-04c91866a5e7480687fd58bf694b68a52025-02-03T01:09:57ZengWileyInternational Journal of Pediatrics1687-97401687-97592009-01-01200910.1155/2009/274768274768Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight InfantsDaijiro Takahashi0Tomohiko Nakamura1Reiko Shigematsu2Miyu Matsui3Shunsuke Araki4Kazuyasu Kubo5Hiroshi Sato6Akira Shirahata7Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanDivision of Neonatology, Nagano Children’s Hospital, Azumino City, Nagano 399-8288, JapanDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, JapanWe conducted a retrospective case series study to evaluate the safety of fosfluconazole prophylaxis for preventing invasive fungal infection in VLBW infants with a central vascular access. Fosfluconazole was administered intravenously at a dose of 6 mg/kg everyday during which time a central venous catheter was placed. A total of 23 infants met the criteria for enrollment in our study. No cases of fungal infection were detected during the central venous catheter placement in the group. None of the infants had an elevated β-D-glucan, and all of them were still alive at discharge. Regarding the liver and renal function, no statistically significant differences were observed before and at the end of fosfluconazole prophylaxis. The results of this study demonstrate that fosfluconazole prophylaxis in preventing invasive fungal infection was well tolerated by VLBW infants. This is a first report to describe antifungal prophylaxis using fosfluconazole for VLBW infants.http://dx.doi.org/10.1155/2009/274768 |
| spellingShingle | Daijiro Takahashi Tomohiko Nakamura Reiko Shigematsu Miyu Matsui Shunsuke Araki Kazuyasu Kubo Hiroshi Sato Akira Shirahata Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants International Journal of Pediatrics |
| title | Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants |
| title_full | Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants |
| title_fullStr | Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants |
| title_full_unstemmed | Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants |
| title_short | Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants |
| title_sort | fosfluconazole for antifungal prophylaxis in very low birth weight infants |
| url | http://dx.doi.org/10.1155/2009/274768 |
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