Obsessive–Compulsive Symptoms in Neurologic Disease: A Review

Obsessive–compulsive disorder (OCD) is an increasingly recognized disorder with a prevalence of 2–3% (Robins et al., 1984). Once thought to be psychodynamic in origin, OCD is now generally recognized as having a neurobiological cause. Although the exact pathophysiology of OCD in its pure form remain...

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Main Authors: M. S. George, J. A. Melvin, C. H. Kellner
Format: Article
Language:English
Published: Wiley 1992-01-01
Series:Behavioural Neurology
Online Access:http://dx.doi.org/10.3233/BEN-1992-5101
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author M. S. George
J. A. Melvin
C. H. Kellner
author_facet M. S. George
J. A. Melvin
C. H. Kellner
author_sort M. S. George
collection DOAJ
description Obsessive–compulsive disorder (OCD) is an increasingly recognized disorder with a prevalence of 2–3% (Robins et al., 1984). Once thought to be psychodynamic in origin, OCD is now generally recognized as having a neurobiological cause. Although the exact pathophysiology of OCD in its pure form remains unknown, there are numerous reports of obsessive–compulsive symptoms arising in the setting of known neurological disease. In this paper, we review the reported cases of obsessive–compulsive symptoms associated with neurologic diseases and outline the known facts about the underlying neurobiology of OCD. Finally, we synthesize these findings into a proposed theory of the pathophysiology of OCD, in both its pure form and when it accompanies other neurological illness.
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spelling doaj-art-04bd4293b08f43818216564c507627202025-02-03T05:52:40ZengWileyBehavioural Neurology0953-41801875-85841992-01-015131010.3233/BEN-1992-5101Obsessive–Compulsive Symptoms in Neurologic Disease: A ReviewM. S. George0J. A. Melvin1C. H. Kellner2Departments of Neurology, and Psychiatry and Behavioral Sciences, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425-0742, USADepartments of Neurology, and Psychiatry and Behavioral Sciences, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425-0742, USADepartments of Neurology, and Psychiatry and Behavioral Sciences, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425-0742, USAObsessive–compulsive disorder (OCD) is an increasingly recognized disorder with a prevalence of 2–3% (Robins et al., 1984). Once thought to be psychodynamic in origin, OCD is now generally recognized as having a neurobiological cause. Although the exact pathophysiology of OCD in its pure form remains unknown, there are numerous reports of obsessive–compulsive symptoms arising in the setting of known neurological disease. In this paper, we review the reported cases of obsessive–compulsive symptoms associated with neurologic diseases and outline the known facts about the underlying neurobiology of OCD. Finally, we synthesize these findings into a proposed theory of the pathophysiology of OCD, in both its pure form and when it accompanies other neurological illness.http://dx.doi.org/10.3233/BEN-1992-5101
spellingShingle M. S. George
J. A. Melvin
C. H. Kellner
Obsessive–Compulsive Symptoms in Neurologic Disease: A Review
Behavioural Neurology
title Obsessive–Compulsive Symptoms in Neurologic Disease: A Review
title_full Obsessive–Compulsive Symptoms in Neurologic Disease: A Review
title_fullStr Obsessive–Compulsive Symptoms in Neurologic Disease: A Review
title_full_unstemmed Obsessive–Compulsive Symptoms in Neurologic Disease: A Review
title_short Obsessive–Compulsive Symptoms in Neurologic Disease: A Review
title_sort obsessive compulsive symptoms in neurologic disease a review
url http://dx.doi.org/10.3233/BEN-1992-5101
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