DLX4 regulates rheumatoid arthritis fibroblast-like synoviocytes invasiveness and a cancer transcriptomic signature

DLX4 regulates rheumatoid arthritis fibroblast-like synoviocytes invasiveness and a cancer transcriptomic signature

Abstract The fibroblast-like synoviocyte (FLS) has a central role in rheumatoid arthritis (RA) pathogenesis and its invasive behavior strongly correlates with disease severity and joint damage. Yet, the regulation of FLS invasiveness is incompletely understood. Distal-less homeobox 4 (DLX4) is a tra...

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Bibliographic Details
Main Authors: Teresina Laragione, Carolyn Harris, Percio S. Gulko
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Rheumatoid arthritis
Transcription factor
Oxidative stress
TLR
RHO GTPase
HMOX1
Online Access:https://doi.org/10.1038/s41598-025-08960-w
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