Comprehensive single-cell transcriptomic reveals different destinies of melanocytes and dynamic changes of immune microenvironment in a psychological stress-induced leukoderma and leukotrichia mouse model

Comprehensive single-cell transcriptomic reveals different destinies of melanocytes and dynamic changes of immune microenvironment in a psychological stress-induced leukoderma and leukotrichia mouse model

Abstract Background Vitiligo is an acquired skin depigmentation disorder often accompanied by leukoderma and leukotrichia. Half of vitiligo patients experience episodes of stress. Methods We established a chronic unpredictable mild stimulation (CUMS) model in C57BL/6 J mice to simulate chronic menta...

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Bibliographic Details
Main Authors: Xuechen Cao, Yongkai Yu, Hang Yao, Yujie Zheng, Jiawei Lu, Yifei Feng, Tongxin Pei, Ziyu Li, Ming Lu, Yan Lu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Chronic unpredictable mild stress
Single-cell sequencing
Melanocyte stem cells
CXCL16
CXCR6
Innate immunity
Online Access:https://doi.org/10.1186/s10020-025-01236-z
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