A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients
This meta-analysis aims to screen the risk factors for severe illness and death and provide help for early clinical treatment of the new coronavirus (COVID-19). Based on a comprehensive search of PubMed, Embase, and Web of Science databases, we included studies that explored the cause and risk facto...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2021/6660930 |
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| _version_ | 1832560015550971904 |
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| author | Pengqiang Du Dandan Li Aifeng Wang Su Shen Zhichao Ma Xingang Li |
| author_facet | Pengqiang Du Dandan Li Aifeng Wang Su Shen Zhichao Ma Xingang Li |
| author_sort | Pengqiang Du |
| collection | DOAJ |
| description | This meta-analysis aims to screen the risk factors for severe illness and death and provide help for early clinical treatment of the new coronavirus (COVID-19). Based on a comprehensive search of PubMed, Embase, and Web of Science databases, we included studies that explored the cause and risk factors for severe illness and death in COVID-19 patients. We evaluated the strength of this relationship using odds ratios (ORs) with 95% confidence intervals (CIs). A total of 17 articles were included; 16 of the 17 articles were from China, and the risk factors associated with severe illness and death were age, sex, and multiple comorbidities. Advanced age (≥65 years, severe illness, OR = 2.62; death, OR = 6.00), male (severe illness, OR = 1.49; death, OR = 1.54), chronic respiratory diseases (severe illness, OR = 5.67; death, OR = 3.72), diabetes (severe illness, OR = 3.27; death, OR = 2.60), hypertension (severe illness, OR = 3.08; death, OR = 3.53), chronic kidney disease (severe illness, OR = 3.59; death, OR = 5.38), and cardiovascular diseases (severe illness, OR = 3.87; death, OR = 4.91) were all risk factors. For COVID-19 patients, advanced age, male, and patients with chronic disease are at higher risk of developing severe illness or even death. |
| format | Article |
| id | doaj-art-04a5df617b3f4980900d9774191c9592 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-04a5df617b3f4980900d9774191c95922025-02-03T01:28:31ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932021-01-01202110.1155/2021/66609306660930A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 PatientsPengqiang Du0Dandan Li1Aifeng Wang2Su Shen3Zhichao Ma4Xingang Li5Department of Pharmacy, Fuwai Central China Cardiovascular Hospital, Henan Provincial People’s Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, ChinaDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Pharmacy, Fuwai Central China Cardiovascular Hospital, Henan Provincial People’s Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, ChinaDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Pharmacy, Affiliated Hospital of Chifeng University, Chifeng, Inner Mongolia 024000, ChinaDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaThis meta-analysis aims to screen the risk factors for severe illness and death and provide help for early clinical treatment of the new coronavirus (COVID-19). Based on a comprehensive search of PubMed, Embase, and Web of Science databases, we included studies that explored the cause and risk factors for severe illness and death in COVID-19 patients. We evaluated the strength of this relationship using odds ratios (ORs) with 95% confidence intervals (CIs). A total of 17 articles were included; 16 of the 17 articles were from China, and the risk factors associated with severe illness and death were age, sex, and multiple comorbidities. Advanced age (≥65 years, severe illness, OR = 2.62; death, OR = 6.00), male (severe illness, OR = 1.49; death, OR = 1.54), chronic respiratory diseases (severe illness, OR = 5.67; death, OR = 3.72), diabetes (severe illness, OR = 3.27; death, OR = 2.60), hypertension (severe illness, OR = 3.08; death, OR = 3.53), chronic kidney disease (severe illness, OR = 3.59; death, OR = 5.38), and cardiovascular diseases (severe illness, OR = 3.87; death, OR = 4.91) were all risk factors. For COVID-19 patients, advanced age, male, and patients with chronic disease are at higher risk of developing severe illness or even death.http://dx.doi.org/10.1155/2021/6660930 |
| spellingShingle | Pengqiang Du Dandan Li Aifeng Wang Su Shen Zhichao Ma Xingang Li A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients |
| title_full | A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients |
| title_fullStr | A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients |
| title_full_unstemmed | A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients |
| title_short | A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients |
| title_sort | systematic review and meta analysis of risk factors associated with severity and death in covid 19 patients |
| url | http://dx.doi.org/10.1155/2021/6660930 |
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