A Novel and Green UFLC-MS/MS Method for Quantification of Amantadine and Levodopa in Polymeric Nanoparticles: Application to determine Drug loading (%DL), Drug entrapment (%DEE) and Drug release profile

A Novel and Green UFLC-MS/MS Method for Quantification of Amantadine and Levodopa in Polymeric Nanoparticles: Application to determine Drug loading (%DL), Drug entrapment (%DEE) and Drug release profile

Introduction: Levodopa, a dopamine precursor, widely prescribed drug in Parkinson’s disease management possesses a side effect of Levodopa-induced dyskinesia (LID). Amantadine hydrochloride, an NMDA receptor antagonist is co-encapsulated along with levodopa and formulates as polymeric nanoparticles...

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Bibliographic Details
Main Authors: Akanksha Lahiri, Balamuralidhara V, Hemanth Vikram PR, Karthika Paul
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Talanta Open
Subjects:
Amantadine
Levodopa
LC-MS/MS
Drug loading
Drug entrapment
Greenness assessment
Online Access:http://www.sciencedirect.com/science/article/pii/S2666831925000785
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