Response mechanism of heat-sensitive neurons under combined noise stimulation
Patients with congenital analgesia who lack the ability to sense temperature generally face low survival rates, highlighting a critical need to understand the underlying mechanisms of heat sensation. While previous research has focused on modeling neural responses to stimuli, the specific mechanisms...
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| Language: | English |
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AIMS Press
2024-11-01
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/era.2024298 |
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| author | Yunhai Wang Guodong Huang Rui Zhu Shu Zhou Yuan Chai |
| author_facet | Yunhai Wang Guodong Huang Rui Zhu Shu Zhou Yuan Chai |
| author_sort | Yunhai Wang |
| collection | DOAJ |
| description | Patients with congenital analgesia who lack the ability to sense temperature generally face low survival rates, highlighting a critical need to understand the underlying mechanisms of heat sensation. While previous research has focused on modeling neural responses to stimuli, the specific mechanisms by which heat-sensitive neurons respond to external temperature changes remain unclear. This gap in knowledge is particularly relevant, as identifying how these neurons react to diverse stimuli can provide insight into sensory deficits linked to congenital analgesia. In this study, we developed a model of heat-sensitive neurons based on the FitzHugh-Nagumo (FHN) neural circuit to investigate neuronal response patterns to external heat stimuli. Two distinct stimulus patterns, each combined with Gaussian white noise, were applied to the model to induce varied firing modes. By calculating the Hamilton energy for each firing mode, we quantified the impact of each external stimulus on neuronal activity. A correlation function was further defined to explore how different stimuli influence the selection of firing modes. Simulation results demonstrate that heat-sensitive neurons show a preferential response to stimuli that induce spike discharge over stimuli that induce r-clonic patterns, as seen in changes to the periodic attractor contours. When exposed to Chua's circuit stimulus, chaotic emission patterns reveal significant shifts in attractor contour, indicating a strong response to spike, r-clonic, and periodic stimuli. These findings suggest that external stimuli capable of inducing spike-and-wave or r-clonic patterns are sensitively detected by thermosensitive neurons, leading to heightened Hamilton energy release and increased regularity in neural activity. This study enhances our understanding of thermosensitive neuronal dynamics under complex stimuli, shedding light on potential response mechanisms relevant to sensory dysfunction in congenital analgesia and advancing the broader field of neural response modeling. |
| format | Article |
| id | doaj-art-049f1ee9d75a4f77b53d983191e849c7 |
| institution | Kabale University |
| issn | 2688-1594 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Electronic Research Archive |
| spelling | doaj-art-049f1ee9d75a4f77b53d983191e849c72025-01-23T07:53:01ZengAIMS PressElectronic Research Archive2688-15942024-11-0132116405642310.3934/era.2024298Response mechanism of heat-sensitive neurons under combined noise stimulationYunhai Wang0Guodong Huang1Rui Zhu2Shu Zhou3Yuan Chai4School of Mathematics and Physics, Shanghai University of Electric Power, Shanghai 201306, ChinaSchool of Mathematics and Physics, Shanghai University of Electric Power, Shanghai 201306, ChinaSchool of Mathematics and Physics, Shanghai University of Electric Power, Shanghai 201306, ChinaSchool of Mathematics and Physics, Shanghai University of Electric Power, Shanghai 201306, ChinaSchool of Mathematics and Physics, Shanghai University of Electric Power, Shanghai 201306, ChinaPatients with congenital analgesia who lack the ability to sense temperature generally face low survival rates, highlighting a critical need to understand the underlying mechanisms of heat sensation. While previous research has focused on modeling neural responses to stimuli, the specific mechanisms by which heat-sensitive neurons respond to external temperature changes remain unclear. This gap in knowledge is particularly relevant, as identifying how these neurons react to diverse stimuli can provide insight into sensory deficits linked to congenital analgesia. In this study, we developed a model of heat-sensitive neurons based on the FitzHugh-Nagumo (FHN) neural circuit to investigate neuronal response patterns to external heat stimuli. Two distinct stimulus patterns, each combined with Gaussian white noise, were applied to the model to induce varied firing modes. By calculating the Hamilton energy for each firing mode, we quantified the impact of each external stimulus on neuronal activity. A correlation function was further defined to explore how different stimuli influence the selection of firing modes. Simulation results demonstrate that heat-sensitive neurons show a preferential response to stimuli that induce spike discharge over stimuli that induce r-clonic patterns, as seen in changes to the periodic attractor contours. When exposed to Chua's circuit stimulus, chaotic emission patterns reveal significant shifts in attractor contour, indicating a strong response to spike, r-clonic, and periodic stimuli. These findings suggest that external stimuli capable of inducing spike-and-wave or r-clonic patterns are sensitively detected by thermosensitive neurons, leading to heightened Hamilton energy release and increased regularity in neural activity. This study enhances our understanding of thermosensitive neuronal dynamics under complex stimuli, shedding light on potential response mechanisms relevant to sensory dysfunction in congenital analgesia and advancing the broader field of neural response modeling.https://www.aimspress.com/article/doi/10.3934/era.2024298piezoelectric neuronneural circuithamilton energyfiring modesnoise |
| spellingShingle | Yunhai Wang Guodong Huang Rui Zhu Shu Zhou Yuan Chai Response mechanism of heat-sensitive neurons under combined noise stimulation Electronic Research Archive piezoelectric neuron neural circuit hamilton energy firing modes noise |
| title | Response mechanism of heat-sensitive neurons under combined noise stimulation |
| title_full | Response mechanism of heat-sensitive neurons under combined noise stimulation |
| title_fullStr | Response mechanism of heat-sensitive neurons under combined noise stimulation |
| title_full_unstemmed | Response mechanism of heat-sensitive neurons under combined noise stimulation |
| title_short | Response mechanism of heat-sensitive neurons under combined noise stimulation |
| title_sort | response mechanism of heat sensitive neurons under combined noise stimulation |
| topic | piezoelectric neuron neural circuit hamilton energy firing modes noise |
| url | https://www.aimspress.com/article/doi/10.3934/era.2024298 |
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