Effect of Whole‐Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain Metastasis
ABSTRACT This study aims to investigate the incidence of acute mastoiditis in patients with brain metastases undergoing whole‐brain radiotherapy (WBRT). A retrospective analysis was conducted on patients with brain metastases who received different doses of WBRT. The incidence of acute mastoiditis w...
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Wiley
2025-06-01
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| Series: | Clinical and Translational Science |
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| Online Access: | https://doi.org/10.1111/cts.70269 |
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| author | Xudong Zhang Ying Huang Hongfei Li Yuntong Pei Fanyang Kong Qian Zhang Yadong Song Yunji Wang Guowen Li |
| author_facet | Xudong Zhang Ying Huang Hongfei Li Yuntong Pei Fanyang Kong Qian Zhang Yadong Song Yunji Wang Guowen Li |
| author_sort | Xudong Zhang |
| collection | DOAJ |
| description | ABSTRACT This study aims to investigate the incidence of acute mastoiditis in patients with brain metastases undergoing whole‐brain radiotherapy (WBRT). A retrospective analysis was conducted on patients with brain metastases who received different doses of WBRT. The incidence of acute mastoiditis within 6 months post‐radiotherapy was observed. Patients were divided into four groups based on the radiation dose: 25, 30, 36 and 40 Gy. The incidence of mastoiditis in each group was statistically analyzed. A total of 209 patients were followed up, with no cases lost to follow‐up, and the follow‐up time was 6 months. The results showed that the number of patients with middle ear mastoiditis was 6 (24%) in group A, 101 (67%) in group B, 12 (80%) in group C and 15 (83%) in group D, and there was a statistically significant difference between the four groups (χ2 = 22.525, p < 0.001). The incidence of acute mastoiditis in patients with brain metastases post‐WBRT is positively correlated with the radiation dose. Higher doses not only increase the risk of mastoiditis but also potentially lead to more severe damage to the middle ear and mastoid regions. Therefore, careful dose management and preventive measures are recommended in WBRT planning to reduce the risk of such complications. |
| format | Article |
| id | doaj-art-049a42e7992a4a9ea284db7fa9f5ea7e |
| institution | Kabale University |
| issn | 1752-8054 1752-8062 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
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| series | Clinical and Translational Science |
| spelling | doaj-art-049a42e7992a4a9ea284db7fa9f5ea7e2025-08-20T03:29:52ZengWileyClinical and Translational Science1752-80541752-80622025-06-01186n/an/a10.1111/cts.70269Effect of Whole‐Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain MetastasisXudong Zhang0Ying Huang1Hongfei Li2Yuntong Pei3Fanyang Kong4Qian Zhang5Yadong Song6Yunji Wang7Guowen Li8Department of Radiotherapy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Magnetic Resonance The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou Henan ChinaDepartment of Radiotherapy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Radiotherapy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Radiotherapy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Radiotherapy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Radiotherapy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Radiotherapy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Radiotherapy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaABSTRACT This study aims to investigate the incidence of acute mastoiditis in patients with brain metastases undergoing whole‐brain radiotherapy (WBRT). A retrospective analysis was conducted on patients with brain metastases who received different doses of WBRT. The incidence of acute mastoiditis within 6 months post‐radiotherapy was observed. Patients were divided into four groups based on the radiation dose: 25, 30, 36 and 40 Gy. The incidence of mastoiditis in each group was statistically analyzed. A total of 209 patients were followed up, with no cases lost to follow‐up, and the follow‐up time was 6 months. The results showed that the number of patients with middle ear mastoiditis was 6 (24%) in group A, 101 (67%) in group B, 12 (80%) in group C and 15 (83%) in group D, and there was a statistically significant difference between the four groups (χ2 = 22.525, p < 0.001). The incidence of acute mastoiditis in patients with brain metastases post‐WBRT is positively correlated with the radiation dose. Higher doses not only increase the risk of mastoiditis but also potentially lead to more severe damage to the middle ear and mastoid regions. Therefore, careful dose management and preventive measures are recommended in WBRT planning to reduce the risk of such complications.https://doi.org/10.1111/cts.70269acute mastoiditisbrain metastasesradiation doseradiotherapy complicationswhole‐brain radiotherapy |
| spellingShingle | Xudong Zhang Ying Huang Hongfei Li Yuntong Pei Fanyang Kong Qian Zhang Yadong Song Yunji Wang Guowen Li Effect of Whole‐Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain Metastasis Clinical and Translational Science acute mastoiditis brain metastases radiation dose radiotherapy complications whole‐brain radiotherapy |
| title | Effect of Whole‐Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain Metastasis |
| title_full | Effect of Whole‐Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain Metastasis |
| title_fullStr | Effect of Whole‐Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain Metastasis |
| title_full_unstemmed | Effect of Whole‐Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain Metastasis |
| title_short | Effect of Whole‐Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain Metastasis |
| title_sort | effect of whole brain radiotherapy dose on the occurrence of otitis media and mastoiditis in patients with lung cancer with brain metastasis |
| topic | acute mastoiditis brain metastases radiation dose radiotherapy complications whole‐brain radiotherapy |
| url | https://doi.org/10.1111/cts.70269 |
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