Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio
Background. High adiponectin/leptin ratio may be protective from metabolic risks imparted by high triglyceride, low HDL, and insulin resistance. Methods. This cross-sectional study examines plasma adipokine levels in 428 adult men who were subgrouped according to low (<6.5 μg...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2013/409679 |
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| _version_ | 1832545759548932096 |
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| author | Gloria Lena Vega Scott M. Grundy |
| author_facet | Gloria Lena Vega Scott M. Grundy |
| author_sort | Gloria Lena Vega |
| collection | DOAJ |
| description | Background. High adiponectin/leptin ratio may be protective from metabolic risks imparted by high triglyceride, low HDL, and insulin resistance. Methods. This cross-sectional study examines plasma adipokine levels in 428 adult men
who were subgrouped according to low (<6.5 μg/mL)and high (≥6.5 μg/mL)adiponectin levels or a low or high ratio of adiponectin/leptin. Results. Men with high adiponectin/leptin ratio had lower plasma triglyceride and higher HDL cholesterol than those with low ratio. Similarly, those with high adiponectin/leptin ratio had lower TG/HDL cholesterol ratio and HOMA2-IR than those with low ratio. In contrast, levels of adiponectin or the ratio of adiponectin/leptin did not associate with systolic blood pressure. But the ratio of adiponectin/leptin decreased progressively with the increase in the number of risk factors for metabolic syndrome. Conclusion. Adipokine levels may reflect adipose tissue triglyceride storage capacity and insulin sensitivity. Leptin is an index of fat mass, and adiponectin is a biomarker of triglyceride metabolism and insulin sensitivity. Men with high adiponectin/leptin ratios have better triglyceride profile and insulin sensitivity than men with a low ratio regardless of waist girth. |
| format | Article |
| id | doaj-art-048e3b08d9034173a06cdd324ea6e330 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-048e3b08d9034173a06cdd324ea6e3302025-02-03T07:24:39ZengWileyJournal of Obesity2090-07082090-07162013-01-01201310.1155/2013/409679409679Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin RatioGloria Lena Vega0Scott M. Grundy1Center for Human Nutrition and Departments of Clinical Nutrition, Internal Medicine and The Metabolic Unit of the Veterans Administration North Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9052, USACenter for Human Nutrition and Departments of Clinical Nutrition, Internal Medicine and The Metabolic Unit of the Veterans Administration North Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9052, USABackground. High adiponectin/leptin ratio may be protective from metabolic risks imparted by high triglyceride, low HDL, and insulin resistance. Methods. This cross-sectional study examines plasma adipokine levels in 428 adult men who were subgrouped according to low (<6.5 μg/mL)and high (≥6.5 μg/mL)adiponectin levels or a low or high ratio of adiponectin/leptin. Results. Men with high adiponectin/leptin ratio had lower plasma triglyceride and higher HDL cholesterol than those with low ratio. Similarly, those with high adiponectin/leptin ratio had lower TG/HDL cholesterol ratio and HOMA2-IR than those with low ratio. In contrast, levels of adiponectin or the ratio of adiponectin/leptin did not associate with systolic blood pressure. But the ratio of adiponectin/leptin decreased progressively with the increase in the number of risk factors for metabolic syndrome. Conclusion. Adipokine levels may reflect adipose tissue triglyceride storage capacity and insulin sensitivity. Leptin is an index of fat mass, and adiponectin is a biomarker of triglyceride metabolism and insulin sensitivity. Men with high adiponectin/leptin ratios have better triglyceride profile and insulin sensitivity than men with a low ratio regardless of waist girth.http://dx.doi.org/10.1155/2013/409679 |
| spellingShingle | Gloria Lena Vega Scott M. Grundy Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio Journal of Obesity |
| title | Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio |
| title_full | Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio |
| title_fullStr | Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio |
| title_full_unstemmed | Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio |
| title_short | Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio |
| title_sort | metabolic risk susceptibility in men is partially related to adiponectin leptin ratio |
| url | http://dx.doi.org/10.1155/2013/409679 |
| work_keys_str_mv | AT glorialenavega metabolicrisksusceptibilityinmenispartiallyrelatedtoadiponectinleptinratio AT scottmgrundy metabolicrisksusceptibilityinmenispartiallyrelatedtoadiponectinleptinratio |