Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes
Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000050 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Monocyte chemotactic protein (MCP-1) is a specific monocyte
chemoattractant and activating factor produced by both immune cells
(mononuclear phagocytes and lymphocytes) and non-immune cells
(parenchymal and stromal cells). In order to define the conditions
under which human monocytes express MCP-1, monocytes were exposed to
IFN-γ, IL- lβ, TNF-α, IL-4 or PHA under serum free
conditions. There was no significant MCP-1 production by monocytes
following exposure to IL-lβ, TNF-α or IL-4. In contrast,
stimulation with IFN-γ resulted in a dose dependent increase
in MCP-1 protein and mRNA expression. Simultaneous stimulation with
IFN-γ and IL-1β or TNF-α resulted in no further
increase in MCP-1 production. It is concluded that IFN-γ,
primarily a product of TH1 T lymphocytes, stimulates the expression
of MCP-1 by monocytes. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |