Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms

Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms

Abstract Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) mol...

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Main Authors: Dennyson Leandro M. Fonseca, Maj Jäpel, Michael Adu Gyamfi, Igor Salerno Filgueiras, Gabriela Crispim Baiochi, Yuri Ostrinski, Gilad Halpert, Yael Bublil Lavi, Elroy Vojdani, Thayna Silva-Sousa, Júlia Nakanishi Usuda, Juan Carlo Santos e Silva, Paula P. Freire, Adriel Leal Nóbile, Anny Silva Adri, Pedro Marçal Barcelos, Yohan Lucas Gonçalves Corrêa, Fernando Yuri Nery do Vale, Letícia Oliveira Lopes, Solveig Lea Schmidt, Xiaoqing Wang, Carl Vahldieck, Benedikt Fels, Lena F. Schimke, Gustavo Cabral-Miranda, Mario Hiroyuki Hirata, Taj Ali AKhan, Yen-Rei A. Yu, Rodrigo JS Dalmolin, Howard Amital, Aristo Vojdani, Haroldo Dutra Dias, Helder Nakaya, Hans D. Ochs, Jonathan I. Silverberg, Jason Zimmerman, Israel Zyskind, Avi Z. Rosenberg, Kai Schulze-Forster, Harald Heidecke, Rusan Catar, Guido Moll, Alexander Hackel, Kristina Kusche-Vihrog, Yehuda Shoenfeld, Gabriela Riemekasten, Reza Akbarzadeh, Alexandre H. C. Marques, Otavio Cabral-Marques
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-025-00488-z
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https://doi.org/10.1038/s41540-025-00488-z

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