Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study
Objective. To investigate the natural history and related factors of the pancreatic β-cell function in Chinese type 1 diabetic patients from 3C study Shantou center. Method. Stimulated C-peptide levels from follow-up data of 201 individuals in 3C study Shantou subgroup starting in 2012 were used. Re...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9946874 |
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| _version_ | 1832561403288879104 |
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| author | Kun Lin Xiaoping Yang Yixi Wu Shuru Chen Qiong Zeng |
| author_facet | Kun Lin Xiaoping Yang Yixi Wu Shuru Chen Qiong Zeng |
| author_sort | Kun Lin |
| collection | DOAJ |
| description | Objective. To investigate the natural history and related factors of the pancreatic β-cell function in Chinese type 1 diabetic patients from 3C study Shantou center. Method. Stimulated C-peptide levels from follow-up data of 201 individuals in 3C study Shantou subgroup starting in 2012 were used. Residual β-cell function was defined as stimulated C−peptide level≥0.2 pmol/mL, on the basis of cut-points derived from the Diabetes Control and Complications Trial (DCCT). Results. 36.8% of patients had residual β-cell function, and the percentage was 68.2% in newly diagnosed diabetic patients. COX regression analysis indicated that the age of diagnosis, HbA1C level, and duration were independent factors of residual β-cell function in individuals with ≤5 years duration, but in those with duration ≥5 years, only the age of diagnosis was a predictor. The pancreatic β-cell function mainly declined in the first 5 years of the duration, and the rate of decline was correlated negatively with the duration and age of diagnosis. Receiver operating characteristic (ROC) analysis indicated that the cut-off point of stimulated C-peptide was 0.615 pmol/mL in patients with <5 years duration to have 7% HbA1c. Conclusion. Age at diagnosis was the strongest predictor for residual C-peptide. There was a more rapid decline of stimulated C-peptide in duration ≤5 years and younger patients. Therefore, intervention therapies of β-cells should start from the early stage, and the recommended target goal of stimulated C-peptide is 0.615 pmol/mL or above. |
| format | Article |
| id | doaj-art-04765248d844465fb3ee01e37c52135a |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-04765248d844465fb3ee01e37c52135a2025-02-03T01:25:07ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/99468749946874Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C StudyKun Lin0Xiaoping Yang1Yixi Wu2Shuru Chen3Qiong Zeng4Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaShenzhen Huada Gene Technology Service Co., Ltd, Shenzhen, ChinaDepartment of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaObjective. To investigate the natural history and related factors of the pancreatic β-cell function in Chinese type 1 diabetic patients from 3C study Shantou center. Method. Stimulated C-peptide levels from follow-up data of 201 individuals in 3C study Shantou subgroup starting in 2012 were used. Residual β-cell function was defined as stimulated C−peptide level≥0.2 pmol/mL, on the basis of cut-points derived from the Diabetes Control and Complications Trial (DCCT). Results. 36.8% of patients had residual β-cell function, and the percentage was 68.2% in newly diagnosed diabetic patients. COX regression analysis indicated that the age of diagnosis, HbA1C level, and duration were independent factors of residual β-cell function in individuals with ≤5 years duration, but in those with duration ≥5 years, only the age of diagnosis was a predictor. The pancreatic β-cell function mainly declined in the first 5 years of the duration, and the rate of decline was correlated negatively with the duration and age of diagnosis. Receiver operating characteristic (ROC) analysis indicated that the cut-off point of stimulated C-peptide was 0.615 pmol/mL in patients with <5 years duration to have 7% HbA1c. Conclusion. Age at diagnosis was the strongest predictor for residual C-peptide. There was a more rapid decline of stimulated C-peptide in duration ≤5 years and younger patients. Therefore, intervention therapies of β-cells should start from the early stage, and the recommended target goal of stimulated C-peptide is 0.615 pmol/mL or above.http://dx.doi.org/10.1155/2021/9946874 |
| spellingShingle | Kun Lin Xiaoping Yang Yixi Wu Shuru Chen Qiong Zeng Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study Journal of Diabetes Research |
| title | Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study |
| title_full | Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study |
| title_fullStr | Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study |
| title_full_unstemmed | Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study |
| title_short | Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study |
| title_sort | residual β cell function in type 1 diabetes followed for 2 years after 3c study |
| url | http://dx.doi.org/10.1155/2021/9946874 |
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