Orbitrap noise structure and method for noise unbiased multivariate analysis

Orbitrap noise structure and method for noise unbiased multivariate analysis

Abstract Orbitrap mass spectrometry is widely used in the life-sciences. However, like all mass spectrometers, non-uniform (heteroscedastic) noise introduces bias in multivariate analysis complicating data interpretation. Here, we study the noise structure of an Orbitrap mass analyser integrated int...

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Main Authors: Michael R. Keenan, Gustavo F. Trindade, Alexander Pirkl, Clare L. Newell, Yuhong Jin, Konstantin Aizikov, Andreas Dannhorn, Junting Zhang, Lidija Matjačić, Henrik Arlinghaus, Anya Eyres, Rasmus Havelund, Richard J. A. Goodwin, Zoltan Takats, Josephine Bunch, Alex P. Gould, Alexander Makarov, Ian S. Gilmore
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61542-2
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