Relationship between ghrelin and thyroid disease: a meta-analysis
BackgroundPrevious studies have identified a close relationship between ghrelin levels and thyroid disease. Ghrelin levels were lower in patients with hyperthyroidism compared with healthy individuals, and increased after treatment. However, other studies have reported inconsistent results. As such,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1505085/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850229285456969728 |
|---|---|
| author | Caihong Xin Jiayi Yao Huijuan Li Xin Sun Huijuan Wang |
| author_facet | Caihong Xin Jiayi Yao Huijuan Li Xin Sun Huijuan Wang |
| author_sort | Caihong Xin |
| collection | DOAJ |
| description | BackgroundPrevious studies have identified a close relationship between ghrelin levels and thyroid disease. Ghrelin levels were lower in patients with hyperthyroidism compared with healthy individuals, and increased after treatment. However, other studies have reported inconsistent results. As such, the association between ghrelin and thyroid disease remains controversial.MethodsA literature search of the Web of Science, Wiley Online Library, Embase, and PubMed databases was performed. The title or abstract search term “thyroid” was used in combination with “ghrelin”. Meta-analysis results are reported as standardized mean difference with corresponding 95% confidence interval (CI).ResultsTwenty-three studies were included in this meta-analysis. Ghrelin levels in patients with hyperthyroidism were significantly lower than those in healthy individuals (SMD: -1.03, 95% CI [-1.75, 0.32]), but significantly higher after effective treatment (SMD: 0.77, 95% CI [0.03, 1.51]). Ghrelin levels were higher, but not significantly, in patients with hypothyroidism compared with healthy controls (SMD: 0.48, 95% CI [-0.13, 1.08]).ConclusionsThis systematic review is the first to evaluate the relationship between ghrelin and thyroid disease. Determining the role of ghrelin in thyroid disease will significantly contribute to understand of symptom or pathomechanism.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024591501. |
| format | Article |
| id | doaj-art-0470ee64eae645c0ad5dbc6740e4d5f3 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-0470ee64eae645c0ad5dbc6740e4d5f32025-08-20T02:04:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15050851505085Relationship between ghrelin and thyroid disease: a meta-analysisCaihong Xin0Jiayi Yao1Huijuan Li2Xin Sun3Huijuan Wang4Department of Endocrinology and Metabolism, Fourth People’s Hospital of Shenyang, Shenyang, ChinaDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Diabetes, Taiping Street Health Center of Xiangcheng District of Suzhou City, Suzhou, ChinaBackgroundPrevious studies have identified a close relationship between ghrelin levels and thyroid disease. Ghrelin levels were lower in patients with hyperthyroidism compared with healthy individuals, and increased after treatment. However, other studies have reported inconsistent results. As such, the association between ghrelin and thyroid disease remains controversial.MethodsA literature search of the Web of Science, Wiley Online Library, Embase, and PubMed databases was performed. The title or abstract search term “thyroid” was used in combination with “ghrelin”. Meta-analysis results are reported as standardized mean difference with corresponding 95% confidence interval (CI).ResultsTwenty-three studies were included in this meta-analysis. Ghrelin levels in patients with hyperthyroidism were significantly lower than those in healthy individuals (SMD: -1.03, 95% CI [-1.75, 0.32]), but significantly higher after effective treatment (SMD: 0.77, 95% CI [0.03, 1.51]). Ghrelin levels were higher, but not significantly, in patients with hypothyroidism compared with healthy controls (SMD: 0.48, 95% CI [-0.13, 1.08]).ConclusionsThis systematic review is the first to evaluate the relationship between ghrelin and thyroid disease. Determining the role of ghrelin in thyroid disease will significantly contribute to understand of symptom or pathomechanism.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024591501.https://www.frontiersin.org/articles/10.3389/fendo.2025.1505085/fullghrelinthyroid diseasehyperthyroidismhypothyroidismmeta - analysis |
| spellingShingle | Caihong Xin Jiayi Yao Huijuan Li Xin Sun Huijuan Wang Relationship between ghrelin and thyroid disease: a meta-analysis Frontiers in Endocrinology ghrelin thyroid disease hyperthyroidism hypothyroidism meta - analysis |
| title | Relationship between ghrelin and thyroid disease: a meta-analysis |
| title_full | Relationship between ghrelin and thyroid disease: a meta-analysis |
| title_fullStr | Relationship between ghrelin and thyroid disease: a meta-analysis |
| title_full_unstemmed | Relationship between ghrelin and thyroid disease: a meta-analysis |
| title_short | Relationship between ghrelin and thyroid disease: a meta-analysis |
| title_sort | relationship between ghrelin and thyroid disease a meta analysis |
| topic | ghrelin thyroid disease hyperthyroidism hypothyroidism meta - analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1505085/full |
| work_keys_str_mv | AT caihongxin relationshipbetweenghrelinandthyroiddiseaseametaanalysis AT jiayiyao relationshipbetweenghrelinandthyroiddiseaseametaanalysis AT huijuanli relationshipbetweenghrelinandthyroiddiseaseametaanalysis AT xinsun relationshipbetweenghrelinandthyroiddiseaseametaanalysis AT huijuanwang relationshipbetweenghrelinandthyroiddiseaseametaanalysis |