Rapid Diagnosis of Bacterial Infections Using Technologies Based on Nucleic Acid Detection
Bacterial identification and antibiotic susceptibility testing methods used in clinical microbiology laboratories generally require at least two days. This long delay often forces physicians to treat patients presumptively with broad-spectrum antibiotics. Novel diagnostic tests based on the detectio...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1999-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1999/872430 |
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| Summary: | Bacterial identification and antibiotic susceptibility testing methods used in clinical microbiology laboratories generally
require at least two days. This long delay often forces physicians to treat patients presumptively with broad-spectrum
antibiotics. Novel diagnostic tests based on the detection of nucleic acids (DNA or RNA) offer a great potential for the
rapid (approximately 1 h) diagnosis of bacterial infections. The present article reviews various aspects of the development
and validation of nucleic acid-based assays suitable for the detection and identification of bacteria as well as for
the detection of associated antibiotic resistance genes. The potential of these assays for routine use in clinical microbiology
laboratories is also discussed. |
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| ISSN: | 1180-2332 |