Recent progress on anti-cancer activity of thiadiazoles: A review
Cancer, a life-threatening condition which has become one of the deadliest disease impacting human health. Conventional drugs have significant side effects and are prone to drug resistance, whereas innovative therapies are costly and place a large load on patients. Despite the fact that several deca...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624006350 |
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| author | C.R. Santhosh Sampath Chinnam Nagaraju Kottam S Amreen Guddekoppa S. Ananthnag G.M. Madhu Samata Gadde Viola Tressa Fernandes Haritha Arnipalli |
| author_facet | C.R. Santhosh Sampath Chinnam Nagaraju Kottam S Amreen Guddekoppa S. Ananthnag G.M. Madhu Samata Gadde Viola Tressa Fernandes Haritha Arnipalli |
| author_sort | C.R. Santhosh |
| collection | DOAJ |
| description | Cancer, a life-threatening condition which has become one of the deadliest disease impacting human health. Conventional drugs have significant side effects and are prone to drug resistance, whereas innovative therapies are costly and place a large load on patients. Despite the fact that several decades of medication research and discovery have produced a number of helpful chemotherapeutic drugs, the hunt for novel chemical entities with enhanced efficacy and safety is still ongoing. Thiadiazoles acts as inhibitors against several specific enzymes or signaling pathways. These compounds are frequently utilized when combined with other anti-cancer drugs to improve their efficacy. Thiadiazoles exhibit beneficial synergistic effects when used with other anticancer treatments like chemotherapy or targeted therapy. They have shown considerable anti-cancer action against various cancer cell lines. The review covers recent anti-cancer research findings from 2021 to 2024. This review aimed to give an overall description of thiadiazoles and analogs which demonstrated potential anti-cancer properties. |
| format | Article |
| id | doaj-art-0466e3ec7a51422eab86ad9e7d599b91 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-0466e3ec7a51422eab86ad9e7d599b912025-01-29T05:00:38ZengElsevierResults in Chemistry2211-71562025-01-0113101939Recent progress on anti-cancer activity of thiadiazoles: A reviewC.R. Santhosh0Sampath Chinnam1Nagaraju Kottam2S Amreen3Guddekoppa S. Ananthnag4G.M. Madhu5Samata Gadde6Viola Tressa Fernandes7Haritha Arnipalli8Department of Chemistry, M.S. Ramaiah Institute of Technology (Autonoumous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, IndiaDepartment of Chemistry, M.S. Ramaiah Institute of Technology (Autonoumous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, India; Corresponding author.Department of Chemistry, M.S. Ramaiah Institute of Technology (Autonoumous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, IndiaDepartment of Chemistry, Jyoti Nivas College (Autonomous), Bengaluru, Karnataka 560095, IndiaDepartment of Chemistry, B.M.S. College of Engineering, Bull Temple Road, Bengaluru, Karnataka 560019, IndiaDepartment of Chemical Engineering, M. S. Ramaiah Institute of Technology, (Autonoumous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, IndiaDepartment of Biotechnology, Acharya Nagarjuna Univeristy, Guntur, Andhra Pradesh 522510, IndiaDepartment of Chemistry, M.S. Ramaiah Institute of Technology (Autonoumous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, IndiaDepartment of Chemistry, M.S. Ramaiah Institute of Technology (Autonoumous Institution, Affiliated to Visvesvaraya Technological University, Belgaum), Bengaluru, Karnataka 560054, IndiaCancer, a life-threatening condition which has become one of the deadliest disease impacting human health. Conventional drugs have significant side effects and are prone to drug resistance, whereas innovative therapies are costly and place a large load on patients. Despite the fact that several decades of medication research and discovery have produced a number of helpful chemotherapeutic drugs, the hunt for novel chemical entities with enhanced efficacy and safety is still ongoing. Thiadiazoles acts as inhibitors against several specific enzymes or signaling pathways. These compounds are frequently utilized when combined with other anti-cancer drugs to improve their efficacy. Thiadiazoles exhibit beneficial synergistic effects when used with other anticancer treatments like chemotherapy or targeted therapy. They have shown considerable anti-cancer action against various cancer cell lines. The review covers recent anti-cancer research findings from 2021 to 2024. This review aimed to give an overall description of thiadiazoles and analogs which demonstrated potential anti-cancer properties.http://www.sciencedirect.com/science/article/pii/S2211715624006350ThiadiazolesAnti-cancerHeterocyclic compoundsCancer cell lines |
| spellingShingle | C.R. Santhosh Sampath Chinnam Nagaraju Kottam S Amreen Guddekoppa S. Ananthnag G.M. Madhu Samata Gadde Viola Tressa Fernandes Haritha Arnipalli Recent progress on anti-cancer activity of thiadiazoles: A review Results in Chemistry Thiadiazoles Anti-cancer Heterocyclic compounds Cancer cell lines |
| title | Recent progress on anti-cancer activity of thiadiazoles: A review |
| title_full | Recent progress on anti-cancer activity of thiadiazoles: A review |
| title_fullStr | Recent progress on anti-cancer activity of thiadiazoles: A review |
| title_full_unstemmed | Recent progress on anti-cancer activity of thiadiazoles: A review |
| title_short | Recent progress on anti-cancer activity of thiadiazoles: A review |
| title_sort | recent progress on anti cancer activity of thiadiazoles a review |
| topic | Thiadiazoles Anti-cancer Heterocyclic compounds Cancer cell lines |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624006350 |
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