Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment
Extranodal Hodgkin lymphoma involving the breast is infrequent. Most cases reported in the literature were diagnosed by histology after lumpectomy. We present a Hodgkin lymphoma mimicking inflammatory breast carcinoma in a 57-year-old woman. The diagnosis was performed by fine-needle aspiration (FNA...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/9256807 |
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| author | Eleni Thodou Maria Befani George Triantafyllidis Theodosia Choreftaki George Kanellis Nikolaos Giannakoulas |
| author_facet | Eleni Thodou Maria Befani George Triantafyllidis Theodosia Choreftaki George Kanellis Nikolaos Giannakoulas |
| author_sort | Eleni Thodou |
| collection | DOAJ |
| description | Extranodal Hodgkin lymphoma involving the breast is infrequent. Most cases reported in the literature were diagnosed by histology after lumpectomy. We present a Hodgkin lymphoma mimicking inflammatory breast carcinoma in a 57-year-old woman. The diagnosis was performed by fine-needle aspiration (FNA) of the breast lesion and the axillary lymph nodes with rapid on-site evaluation followed by immunocytochemistry, and it was confirmed by histology. The patient after first-line chemotherapy developed relapse/refractory disease. Salvage chemotherapy regimens were applied with poor results and severe toxicity. Total remission was achieved with monotherapy of brentuximab vedotin, a novel anti-CD30-targeted antibody drug conjugate. This is a unique case of breast HL with misleading clinical presentation initially diagnosed by cytology. FNA as a minimally invasive diagnostic tool was crucial in avoiding unnecessary breast surgery and further delay of chemotherapy. It is also the first report highlighting the importance of this novel immunotherapy in the management of refractory Hodgkin lymphoma with breast involvement. |
| format | Article |
| id | doaj-art-04618951c833410baafd11a3329851c6 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-04618951c833410baafd11a3329851c62025-02-03T01:10:06ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/92568079256807Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel TreatmentEleni Thodou0Maria Befani1George Triantafyllidis2Theodosia Choreftaki3George Kanellis4Nikolaos Giannakoulas5Department of Pathology, Medical School, University of Thessaly, Viopolis, 41500 Larisa, GreeceHematology, Private Practice, 61 Koumoundourou Str., 38221 Volos, GreeceRadiology, Private Practice, 29 Glavani Str., 38221 Volos, GreeceDepartment of Pathology, “G. Genimmatas”, Athens General Hospital, 154 Mesogeion Ave., 11527 Athens, GreeceDepartment of Hematopathology, “Evangelismos”, General Hospital, 45 Ypsilantou Str., 10676 Athens, GreeceDepartment of Hematology, Medical School, University of Thessaly, Viopolis, 41500 Larisa, GreeceExtranodal Hodgkin lymphoma involving the breast is infrequent. Most cases reported in the literature were diagnosed by histology after lumpectomy. We present a Hodgkin lymphoma mimicking inflammatory breast carcinoma in a 57-year-old woman. The diagnosis was performed by fine-needle aspiration (FNA) of the breast lesion and the axillary lymph nodes with rapid on-site evaluation followed by immunocytochemistry, and it was confirmed by histology. The patient after first-line chemotherapy developed relapse/refractory disease. Salvage chemotherapy regimens were applied with poor results and severe toxicity. Total remission was achieved with monotherapy of brentuximab vedotin, a novel anti-CD30-targeted antibody drug conjugate. This is a unique case of breast HL with misleading clinical presentation initially diagnosed by cytology. FNA as a minimally invasive diagnostic tool was crucial in avoiding unnecessary breast surgery and further delay of chemotherapy. It is also the first report highlighting the importance of this novel immunotherapy in the management of refractory Hodgkin lymphoma with breast involvement.http://dx.doi.org/10.1155/2019/9256807 |
| spellingShingle | Eleni Thodou Maria Befani George Triantafyllidis Theodosia Choreftaki George Kanellis Nikolaos Giannakoulas Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment Case Reports in Hematology |
| title | Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment |
| title_full | Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment |
| title_fullStr | Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment |
| title_full_unstemmed | Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment |
| title_short | Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment |
| title_sort | hodgkin lymphoma mimicking inflammatory breast carcinoma a rare case with diagnostic challenge and novel treatment |
| url | http://dx.doi.org/10.1155/2019/9256807 |
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