Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke
Abstract As global temperatures rise, heat-related chronic health disorders are predicted to become more prevalent. We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07484-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594455352311808 |
|---|---|
| author | Jamal M. Alzahrani Ashley J. Smuder Bryce J. Gambino Cristina Delgado Michael T. Rua Ryan N. Montalvo Finleigh P. Fitton Deborah A. Morse Thomas L. Clanton |
| author_facet | Jamal M. Alzahrani Ashley J. Smuder Bryce J. Gambino Cristina Delgado Michael T. Rua Ryan N. Montalvo Finleigh P. Fitton Deborah A. Morse Thomas L. Clanton |
| author_sort | Jamal M. Alzahrani |
| collection | DOAJ |
| description | Abstract As global temperatures rise, heat-related chronic health disorders are predicted to become more prevalent. We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into chronic disease. Following EHS, mice were followed for 3 months; after two weeks of recovery, half were placed on a Western diet to determine if previous EHS exposure amplifies the negative consequences of an atherogenic diet. When compared to sham exercise controls, EHS-exposed mice exhibit accelerated diet-induced obesity, develop low level cardiac hypertrophy, develop accelerated diet-induced liver steatosis, severe hypoproteinemia and a loss of metabolic flexibility in the myocardium. The latter is characterized by a shift towards predominant glucose metabolism and glycolysis. These results demonstrate that a single exposure to severe exertional heat illness can induce long-lasting and unexpected health consequences in mammals and increased vulnerability to secondary metabolic stressors. |
| format | Article |
| id | doaj-art-045e494550ae4b5c82965bf066e2b1bb |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-045e494550ae4b5c82965bf066e2b1bb2025-01-19T12:35:39ZengNature PortfolioCommunications Biology2399-36422025-01-018111210.1038/s42003-025-07484-3Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat strokeJamal M. Alzahrani0Ashley J. Smuder1Bryce J. Gambino2Cristina Delgado3Michael T. Rua4Ryan N. Montalvo5Finleigh P. Fitton6Deborah A. Morse7Thomas L. Clanton8Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of FloridaDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of FloridaDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of FloridaDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of FloridaDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of FloridaDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of FloridaDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of FloridaDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of FloridaDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of FloridaAbstract As global temperatures rise, heat-related chronic health disorders are predicted to become more prevalent. We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into chronic disease. Following EHS, mice were followed for 3 months; after two weeks of recovery, half were placed on a Western diet to determine if previous EHS exposure amplifies the negative consequences of an atherogenic diet. When compared to sham exercise controls, EHS-exposed mice exhibit accelerated diet-induced obesity, develop low level cardiac hypertrophy, develop accelerated diet-induced liver steatosis, severe hypoproteinemia and a loss of metabolic flexibility in the myocardium. The latter is characterized by a shift towards predominant glucose metabolism and glycolysis. These results demonstrate that a single exposure to severe exertional heat illness can induce long-lasting and unexpected health consequences in mammals and increased vulnerability to secondary metabolic stressors.https://doi.org/10.1038/s42003-025-07484-3 |
| spellingShingle | Jamal M. Alzahrani Ashley J. Smuder Bryce J. Gambino Cristina Delgado Michael T. Rua Ryan N. Montalvo Finleigh P. Fitton Deborah A. Morse Thomas L. Clanton Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke Communications Biology |
| title | Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke |
| title_full | Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke |
| title_fullStr | Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke |
| title_full_unstemmed | Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke |
| title_short | Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke |
| title_sort | mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke |
| url | https://doi.org/10.1038/s42003-025-07484-3 |
| work_keys_str_mv | AT jamalmalzahrani micedevelopobesityandlosemyocardialmetabolicflexibilitymonthsafterexertionalheatstroke AT ashleyjsmuder micedevelopobesityandlosemyocardialmetabolicflexibilitymonthsafterexertionalheatstroke AT brycejgambino micedevelopobesityandlosemyocardialmetabolicflexibilitymonthsafterexertionalheatstroke AT cristinadelgado micedevelopobesityandlosemyocardialmetabolicflexibilitymonthsafterexertionalheatstroke AT michaeltrua micedevelopobesityandlosemyocardialmetabolicflexibilitymonthsafterexertionalheatstroke AT ryannmontalvo micedevelopobesityandlosemyocardialmetabolicflexibilitymonthsafterexertionalheatstroke AT finleighpfitton micedevelopobesityandlosemyocardialmetabolicflexibilitymonthsafterexertionalheatstroke AT deborahamorse micedevelopobesityandlosemyocardialmetabolicflexibilitymonthsafterexertionalheatstroke AT thomaslclanton micedevelopobesityandlosemyocardialmetabolicflexibilitymonthsafterexertionalheatstroke |