Targeting synergetic endothelial inflammation by inhibiting NFKB and JAK-STAT pathways

Targeting synergetic endothelial inflammation by inhibiting NFKB and JAK-STAT pathways

Summary: Multiple systemic vascular inflammatory disorders are associated with endothelial dysfunction and elevated levels of TNFα and IFNγ. Combined TNFα and IFNγ stimulation induces synergetic hyperinflammation in endothelial cells (ECs) through the activation of the NFKB and JAK/STAT pathways. He...

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Bibliographic Details
Main Authors: Stijn A. Groten, Pieter Langerhorst, Georgios Malamas, Alastair Barraclough, Arie J. Hoogendijk, Maartje van den Biggelaar
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:iScience
Subjects:
Biochemistry
Cell biology
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225015688
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