Atrial fibrillation and cognitive impairment: mechanisms, influencing factors, and prospects
IntroductionAtrial fibrillation (AF) is a prevalent cardiac arrhythmia and a significant contributor to cardioembolic stroke, a condition closely linked to cognitive decline. However, research reveals that AF itself is independently associated with an increased risk of cognitive impairment. This hig...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1527802/full |
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| author | Li-Juan Huang Jian-Shu Chen Yu-Zhe Song Peng Chang |
| author_facet | Li-Juan Huang Jian-Shu Chen Yu-Zhe Song Peng Chang |
| author_sort | Li-Juan Huang |
| collection | DOAJ |
| description | IntroductionAtrial fibrillation (AF) is a prevalent cardiac arrhythmia and a significant contributor to cardioembolic stroke, a condition closely linked to cognitive decline. However, research reveals that AF itself is independently associated with an increased risk of cognitive impairment. This high incidence of cognitive decline in AF patients may result from various mechanisms, including reduced cerebral perfusion, microembolism, decreased cardiac output, and chronic inflammation.MethodsThis review synthesizes current evidence on the relationship between AF and cognitive impairment, examines underlying mechanisms of cognitive decline in AF, and explores the roles of AF type, treatment approaches, left atrial characteristics, and associated conditions in cognitive function outcomes.ResultsCognitive outcomes in AF are further influenced by a range of factors, such as left atrial structural parameters, AF type and duration, anticoagulation use, catheter ablation, comorbidities, age, and gender.DiscussionThe review highlights the complex interplay between AF and cognitive impairment, emphasizing the importance of understanding the various mechanisms and factors that contribute to cognitive decline in AF patients. By examining the roles of AF type, treatment approaches, left atrial characteristics, and associated conditions, this review provides insights into potential strategies for mitigating cognitive impairment in AF patients. |
| format | Article |
| id | doaj-art-043cf4a3e88d4c35b9a936b8b8861d9e |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-043cf4a3e88d4c35b9a936b8b8861d9e2025-02-06T07:09:29ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-02-011210.3389/fcvm.2025.15278021527802Atrial fibrillation and cognitive impairment: mechanisms, influencing factors, and prospectsLi-Juan Huang0Jian-Shu Chen1Yu-Zhe Song2Peng Chang3Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaDepartment of Cardiology, Lanzhou University Second Hospital, Lanzhou, ChinaSecond Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaDepartment of Cardiology, Lanzhou University Second Hospital, Lanzhou, ChinaIntroductionAtrial fibrillation (AF) is a prevalent cardiac arrhythmia and a significant contributor to cardioembolic stroke, a condition closely linked to cognitive decline. However, research reveals that AF itself is independently associated with an increased risk of cognitive impairment. This high incidence of cognitive decline in AF patients may result from various mechanisms, including reduced cerebral perfusion, microembolism, decreased cardiac output, and chronic inflammation.MethodsThis review synthesizes current evidence on the relationship between AF and cognitive impairment, examines underlying mechanisms of cognitive decline in AF, and explores the roles of AF type, treatment approaches, left atrial characteristics, and associated conditions in cognitive function outcomes.ResultsCognitive outcomes in AF are further influenced by a range of factors, such as left atrial structural parameters, AF type and duration, anticoagulation use, catheter ablation, comorbidities, age, and gender.DiscussionThe review highlights the complex interplay between AF and cognitive impairment, emphasizing the importance of understanding the various mechanisms and factors that contribute to cognitive decline in AF patients. By examining the roles of AF type, treatment approaches, left atrial characteristics, and associated conditions, this review provides insights into potential strategies for mitigating cognitive impairment in AF patients.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1527802/fullatrial fibrillationcognitive impairmentmechanismsinfluencing factorsprospects |
| spellingShingle | Li-Juan Huang Jian-Shu Chen Yu-Zhe Song Peng Chang Atrial fibrillation and cognitive impairment: mechanisms, influencing factors, and prospects Frontiers in Cardiovascular Medicine atrial fibrillation cognitive impairment mechanisms influencing factors prospects |
| title | Atrial fibrillation and cognitive impairment: mechanisms, influencing factors, and prospects |
| title_full | Atrial fibrillation and cognitive impairment: mechanisms, influencing factors, and prospects |
| title_fullStr | Atrial fibrillation and cognitive impairment: mechanisms, influencing factors, and prospects |
| title_full_unstemmed | Atrial fibrillation and cognitive impairment: mechanisms, influencing factors, and prospects |
| title_short | Atrial fibrillation and cognitive impairment: mechanisms, influencing factors, and prospects |
| title_sort | atrial fibrillation and cognitive impairment mechanisms influencing factors and prospects |
| topic | atrial fibrillation cognitive impairment mechanisms influencing factors prospects |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1527802/full |
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