Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes
We have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amin...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/BCA/2006/59509 |
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| author | Ram K. Agarwal Lakshman Singh Deepak Kumar Sharma |
| author_facet | Ram K. Agarwal Lakshman Singh Deepak Kumar Sharma |
| author_sort | Ram K. Agarwal |
| collection | DOAJ |
| description | We have synthesized a novel series of Schiff bases by condensation
of 4-aminoantipyrine and various aromatic aldehydes followed by
reaction with thiosemicarbazide. These thiosemicarbazones are
potential ligands toward transition metal ions. The reaction of
copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS),
4[N-(4′-methoxybenzalidene) amino] antipyrinethiosemicarbozone
(MBAAPTS), 4[N-(4′-dimethylamino benzalidene) amino]
antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene)
amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the
formation of solid complexes with the general composition
CuX2⋅(H2O)(L)(X = Cl, Br, NO3, NCS, or CH3COO; L = BAAPTS, MBAAPTS, DABAAPTS, or CAAPTS). These complexes were characterized
through elemental analysis, molecular weight, electrical
conductance, infrared, electronic spectra, and magnetic
susceptibilities at room temperature. Copper(II) complexes with
BAAPTS and MBAAPTS were screened for antibacterial and antifungal
properties and have exhibited potential activity. Thermal
stabilities of two representative complexes were also investigated. |
| format | Article |
| id | doaj-art-043877dc6aaa4529bea42abb736c0209 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-043877dc6aaa4529bea42abb736c02092025-02-03T06:11:01ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2006-01-01200610.1155/BCA/2006/5950959509Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic AldehydesRam K. Agarwal0Lakshman Singh1Deepak Kumar Sharma2Department of Chemistry, School of Pure and Applied Sciences, University of the South Pacific, PO Box 1168, Suva, FijiDepartment of Chemistry, Lajpat Rai Postgraduate College, Sahibabad 201005 (Ghaziahad), IndiaDepartment of Chemistry, Lajpat Rai Postgraduate College, Sahibabad 201005 (Ghaziahad), IndiaWe have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS), 4[N-(4′-methoxybenzalidene) amino] antipyrinethiosemicarbozone (MBAAPTS), 4[N-(4′-dimethylamino benzalidene) amino] antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene) amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the formation of solid complexes with the general composition CuX2⋅(H2O)(L)(X = Cl, Br, NO3, NCS, or CH3COO; L = BAAPTS, MBAAPTS, DABAAPTS, or CAAPTS). These complexes were characterized through elemental analysis, molecular weight, electrical conductance, infrared, electronic spectra, and magnetic susceptibilities at room temperature. Copper(II) complexes with BAAPTS and MBAAPTS were screened for antibacterial and antifungal properties and have exhibited potential activity. Thermal stabilities of two representative complexes were also investigated.http://dx.doi.org/10.1155/BCA/2006/59509 |
| spellingShingle | Ram K. Agarwal Lakshman Singh Deepak Kumar Sharma Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes Bioinorganic Chemistry and Applications |
| title | Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes |
| title_full | Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes |
| title_fullStr | Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes |
| title_full_unstemmed | Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes |
| title_short | Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes |
| title_sort | synthesis spectral and biological properties of copper ii complexes of thiosemicarbazones of schiff bases derived from 4 aminoantipyrine and aromatic aldehydes |
| url | http://dx.doi.org/10.1155/BCA/2006/59509 |
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