<i>Bridelia ferruginea</i> Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 Diabetes
Background: It is well-known that persistent hyperglycaemia predisposes individuals with diabetes to oxidative stress. <i>Bridelia ferruginea</i> Benth., a tropical African plant, is known for its antioxidant activity. Methods: This comparative cross-sectional study assessed the oxidativ...
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2025-01-01
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| author | Collins Afriyie Appiah Jennifer Ngounda Mavis Boakye-Yiadom Felix Charles Mills-Robertson Mariette Nel Rabia Johnson Corinna Walsh |
| author_facet | Collins Afriyie Appiah Jennifer Ngounda Mavis Boakye-Yiadom Felix Charles Mills-Robertson Mariette Nel Rabia Johnson Corinna Walsh |
| author_sort | Collins Afriyie Appiah |
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| description | Background: It is well-known that persistent hyperglycaemia predisposes individuals with diabetes to oxidative stress. <i>Bridelia ferruginea</i> Benth., a tropical African plant, is known for its antioxidant activity. Methods: This comparative cross-sectional study assessed the oxidative status and associated parameters in 70 individuals living with type 2 diabetes (ILWT2D) who were receiving standard diabetes treatment and consistently drank Bridelia tea (Bridelia group) compared to 92 ILWT2D receiving standard diabetes treatment only (comparator group). Lipid peroxidation assessed using thiobarbituric acid reactive substances (TBARS) served as an indicator of oxidative stress. In addition, the total antioxidant capacity (TAC), glycated haemoglobin (HbA1c), and dietary intake of antioxidant-rich foods were assessed. Results: The comparator group had significantly better glycaemic control [median HbA1c—7.7% (IQR 6.7–9.4)] than the Bridelia group [9.2% (7.6–11.4)], <i>p</i> = 0.001. The comparator group had been on metformin treatment for a significantly longer period than the Bridelia group (<i>p</i> < 0.0001). Participants in the comparator group consumed antioxidant-rich fruits more frequently (monthly basis) than those in the Bridelia group who ate fruits seldomly (<i>p</i> < 0.0001). There was no significant difference (<i>p</i> = 0.11) observed in oxidative stress levels between the Bridelia group and the comparator group [TBARS: 323.0 ng/L (287.5–374.0) and 317.0 ng/L (272.5–342.0), respectively]. Nonetheless, the Bridelia group had significantly higher antioxidant capacity (<i>p</i> = 0.001) compared to the comparator group [TAC: 1.01 mmol/L (0.93–1.10) versus 0.92 mmol/L (0.84–1.03), respectively]. Participants in the comparator group, who did not drink Bridelia tea, had been on longer metformin treatment with better glycaemic control. However, those who drank the Bridelia tea showed comparable levels of oxidative stress and exhibited elevated antioxidant levels compared to those who did not. Conclusions: Bridelia tea consumption may serve as a sustainable source of antioxidants; however, its effect on mitigating oxidative stress in ILWT2D requires further investigation, particularly given that no significant improvement in TBARS was observed. Future studies are needed to clarify the potential role of Bridelia tea in oxidative stress management in resource-limited settings like Ghana. |
| format | Article |
| id | doaj-art-0435bd423c674a99aae296348c9bd2ee |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-0435bd423c674a99aae296348c9bd2ee2025-01-24T13:28:46ZengMDPI AGDiabetology2673-45402025-01-0161610.3390/diabetology6010006<i>Bridelia ferruginea</i> Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 DiabetesCollins Afriyie Appiah0Jennifer Ngounda1Mavis Boakye-Yiadom2Felix Charles Mills-Robertson3Mariette Nel4Rabia Johnson5Corinna Walsh6Department of Nutrition and Dietetics, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South AfricaDepartment of Nutrition and Dietetics, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South AfricaCentre for Plant Medicine Research, Mampong-Akuapem P.O. Box 73, GhanaDepartment of Biochemistry and Biotechnology, Faculty of Biosciences, College of Science, Kwame Nkrumah University for Science and Technology, P.M.B University Post Office, Kumasi, GhanaDepartment of Biostatistics, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South AfricaBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town 7505, South AfricaDepartment of Nutrition and Dietetics, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South AfricaBackground: It is well-known that persistent hyperglycaemia predisposes individuals with diabetes to oxidative stress. <i>Bridelia ferruginea</i> Benth., a tropical African plant, is known for its antioxidant activity. Methods: This comparative cross-sectional study assessed the oxidative status and associated parameters in 70 individuals living with type 2 diabetes (ILWT2D) who were receiving standard diabetes treatment and consistently drank Bridelia tea (Bridelia group) compared to 92 ILWT2D receiving standard diabetes treatment only (comparator group). Lipid peroxidation assessed using thiobarbituric acid reactive substances (TBARS) served as an indicator of oxidative stress. In addition, the total antioxidant capacity (TAC), glycated haemoglobin (HbA1c), and dietary intake of antioxidant-rich foods were assessed. Results: The comparator group had significantly better glycaemic control [median HbA1c—7.7% (IQR 6.7–9.4)] than the Bridelia group [9.2% (7.6–11.4)], <i>p</i> = 0.001. The comparator group had been on metformin treatment for a significantly longer period than the Bridelia group (<i>p</i> < 0.0001). Participants in the comparator group consumed antioxidant-rich fruits more frequently (monthly basis) than those in the Bridelia group who ate fruits seldomly (<i>p</i> < 0.0001). There was no significant difference (<i>p</i> = 0.11) observed in oxidative stress levels between the Bridelia group and the comparator group [TBARS: 323.0 ng/L (287.5–374.0) and 317.0 ng/L (272.5–342.0), respectively]. Nonetheless, the Bridelia group had significantly higher antioxidant capacity (<i>p</i> = 0.001) compared to the comparator group [TAC: 1.01 mmol/L (0.93–1.10) versus 0.92 mmol/L (0.84–1.03), respectively]. Participants in the comparator group, who did not drink Bridelia tea, had been on longer metformin treatment with better glycaemic control. However, those who drank the Bridelia tea showed comparable levels of oxidative stress and exhibited elevated antioxidant levels compared to those who did not. Conclusions: Bridelia tea consumption may serve as a sustainable source of antioxidants; however, its effect on mitigating oxidative stress in ILWT2D requires further investigation, particularly given that no significant improvement in TBARS was observed. Future studies are needed to clarify the potential role of Bridelia tea in oxidative stress management in resource-limited settings like Ghana.https://www.mdpi.com/2673-4540/6/1/6<i>Bridelia ferruginea</i> teatype 2 diabetesoxidative stressantioxidantsantioxidant-rich foods |
| spellingShingle | Collins Afriyie Appiah Jennifer Ngounda Mavis Boakye-Yiadom Felix Charles Mills-Robertson Mariette Nel Rabia Johnson Corinna Walsh <i>Bridelia ferruginea</i> Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 Diabetes Diabetology <i>Bridelia ferruginea</i> tea type 2 diabetes oxidative stress antioxidants antioxidant-rich foods |
| title | <i>Bridelia ferruginea</i> Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 Diabetes |
| title_full | <i>Bridelia ferruginea</i> Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 Diabetes |
| title_fullStr | <i>Bridelia ferruginea</i> Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 Diabetes |
| title_full_unstemmed | <i>Bridelia ferruginea</i> Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 Diabetes |
| title_short | <i>Bridelia ferruginea</i> Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 Diabetes |
| title_sort | i bridelia ferruginea i tea consumption improves antioxidant status in individuals living with type 2 diabetes |
| topic | <i>Bridelia ferruginea</i> tea type 2 diabetes oxidative stress antioxidants antioxidant-rich foods |
| url | https://www.mdpi.com/2673-4540/6/1/6 |
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