Biocompatibility of three-dimensional thermoplastic elastomer implants compared to that of the sternocephalic muscle flap in repairing partial tracheal defects in New Zealand white rabbits (Oryctolagus cuniculus)

Biocompatibility of three-dimensional thermoplastic elastomer implants compared to that of the sternocephalic muscle flap in repairing partial tracheal defects in New Zealand white rabbits (Oryctolagus cuniculus)

ABSTRACT Purpose: To evaluate the effectiveness and biocompatibility of a three-dimensional (3D) thermoplastic elastomer (TPE) prosthesis for repairing partial tracheal defects using 3D printing with fused deposition modelling. Methods: Thirty-two rabbits underwent partial resection of five trache...

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Main Authors: Marcelo Carrijo da Costa, Ana Carolina Gasques Salgado dos Santos, Ariadne Rein, Gabriel Luiz Montanhim, Gustavo Fernandes, Luis Gustavo Gosuen Gonçalves Dias, Marcella Dall Agnol Leite, Nicolle Pereira Soares, Thiago André Salvitti de Sá Rocha, Marcelo Emilio Beletti, Paola Castro Moraes
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2025-08-01
Series:Acta Cirúrgica Brasileira
Subjects:
Prostheses and Implants
Printing, Three-Dimensional
Rabbits
Histocompatibility
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100235&tlng=en
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Summary:ABSTRACT Purpose: To evaluate the effectiveness and biocompatibility of a three-dimensional (3D) thermoplastic elastomer (TPE) prosthesis for repairing partial tracheal defects using 3D printing with fused deposition modelling. Methods: Thirty-two rabbits underwent partial resection of five tracheal rings and were divided into two groups: the muscular flap group (GFM), which received a sternocephalic muscle flap over the defect; and the TPE group (GTPE), which received a 3D-printed TPE prosthesis. Clinical evaluations were performed at seven, 15, 30, and 60 days postoperatively. Results: Cough was significantly more frequent in the GFM group (p = 0.035). Thermography showed no significant differences in surgical site temperatures between groups or time points. Tracheoscopy revealed more intraluminal secretions in the GTPE group (p = 0.006) and more exuberant tissue formation in the GFM group (p = 0.001). Complete epithelialization was observed in the GFM group after 60 days. Conclusion: The 3D TPE prosthesis demonstrated tissue compatibility and viability as an implant for partial tracheal defects, with minimal respiratory complications during the 60-day evaluation period.
ISSN:1678-2674

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