Prognostic Value of Plasma Pentraxin-3 Levels in Patients with Stable Coronary Artery Disease after Drug-Eluting Stent Implantation
Pentraxin-3 (PTX3) is an inflammatory marker thought to be more specific to cardiovascular inflammation than C-reactive protein (CRP). Our aim was to assess the prognostic value of PTX3 in patients with stable coronary artery disease (CAD) after drug eluting stent (DES) implantation. Plasma PTX3 lev...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/963096 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562852482777088 |
|---|---|
| author | Liu Haibo Guo Xiaofang Wang Chunming Yuan Jie Chen Guozhong Zhang Limei Cao Yong Fang Yu Bao Yingchun Yu Wangjun Ge Junbo |
| author_facet | Liu Haibo Guo Xiaofang Wang Chunming Yuan Jie Chen Guozhong Zhang Limei Cao Yong Fang Yu Bao Yingchun Yu Wangjun Ge Junbo |
| author_sort | Liu Haibo |
| collection | DOAJ |
| description | Pentraxin-3 (PTX3) is an inflammatory marker thought to be more specific to cardiovascular inflammation than C-reactive protein (CRP). Our aim was to assess the prognostic value of PTX3 in patients with stable coronary artery disease (CAD) after drug eluting stent (DES) implantation. Plasma PTX3 levels were measured before percutaneous coronary intervention (PCI) and at 24 h post-PCI in 596 consecutive patients with stable CAD. Patients were followed up for a median of 3 years (range 1–5) for major adverse cardiovascular events (MACEs). We found that the post-PCI plasma PTX3 levels were significantly higher at 24 h after PCI than pre-PCI, patients with MACEs had higher post-PCI PTX3 levels compared with MACEs-free patients, patients with higher post-PCI PTX3 levels (median > 4.384 ng/mL) had a higher risk for MACEs than those with PTX3 < 4.384 ng/mL, and post-PCI PTX3, cTnI, multiple stents, and age but not high-sensitivity CRP (hsCRP) were independently associated with the prevalence of MACEs after DES implantation. The present study shows that post-PCI PTX3 may be a more reliable inflammatory predictor of long-term MACEs in patients with stable CAD undergoing DES implantation than CRP. Measurement of post-PCI PTX3 levels could provide a rationale for risk stratification of patients with stable CAD after DES implantation. |
| format | Article |
| id | doaj-art-042d074b707b456d9eaeaac162ffd4ef |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-042d074b707b456d9eaeaac162ffd4ef2025-02-03T01:21:30ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/963096963096Prognostic Value of Plasma Pentraxin-3 Levels in Patients with Stable Coronary Artery Disease after Drug-Eluting Stent ImplantationLiu Haibo0Guo Xiaofang1Wang Chunming2Yuan Jie3Chen Guozhong4Zhang Limei5Cao Yong6Fang Yu7Bao Yingchun8Yu Wangjun9Ge Junbo10Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaClinical Laboratory Center, Yinzhou People’s Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, ChinaDepartment of Cardiology, Yinzhou People’s Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, ChinaShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Cardiology, Yinzhou People’s Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, ChinaDepartment of Cardiology, Yinzhou People’s Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, ChinaDepartment of Cardiology, Yinzhou People’s Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, ChinaDepartment of Cardiology, Yinzhou People’s Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, ChinaDepartment of Cardiology, Yinzhou People’s Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, ChinaClinical Laboratory Center, Yinzhou People’s Hospital Affiliated to Medical School of Ningbo University, Ningbo 315040, ChinaShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaPentraxin-3 (PTX3) is an inflammatory marker thought to be more specific to cardiovascular inflammation than C-reactive protein (CRP). Our aim was to assess the prognostic value of PTX3 in patients with stable coronary artery disease (CAD) after drug eluting stent (DES) implantation. Plasma PTX3 levels were measured before percutaneous coronary intervention (PCI) and at 24 h post-PCI in 596 consecutive patients with stable CAD. Patients were followed up for a median of 3 years (range 1–5) for major adverse cardiovascular events (MACEs). We found that the post-PCI plasma PTX3 levels were significantly higher at 24 h after PCI than pre-PCI, patients with MACEs had higher post-PCI PTX3 levels compared with MACEs-free patients, patients with higher post-PCI PTX3 levels (median > 4.384 ng/mL) had a higher risk for MACEs than those with PTX3 < 4.384 ng/mL, and post-PCI PTX3, cTnI, multiple stents, and age but not high-sensitivity CRP (hsCRP) were independently associated with the prevalence of MACEs after DES implantation. The present study shows that post-PCI PTX3 may be a more reliable inflammatory predictor of long-term MACEs in patients with stable CAD undergoing DES implantation than CRP. Measurement of post-PCI PTX3 levels could provide a rationale for risk stratification of patients with stable CAD after DES implantation.http://dx.doi.org/10.1155/2014/963096 |
| spellingShingle | Liu Haibo Guo Xiaofang Wang Chunming Yuan Jie Chen Guozhong Zhang Limei Cao Yong Fang Yu Bao Yingchun Yu Wangjun Ge Junbo Prognostic Value of Plasma Pentraxin-3 Levels in Patients with Stable Coronary Artery Disease after Drug-Eluting Stent Implantation Mediators of Inflammation |
| title | Prognostic Value of Plasma Pentraxin-3 Levels in Patients with Stable Coronary Artery Disease after Drug-Eluting Stent Implantation |
| title_full | Prognostic Value of Plasma Pentraxin-3 Levels in Patients with Stable Coronary Artery Disease after Drug-Eluting Stent Implantation |
| title_fullStr | Prognostic Value of Plasma Pentraxin-3 Levels in Patients with Stable Coronary Artery Disease after Drug-Eluting Stent Implantation |
| title_full_unstemmed | Prognostic Value of Plasma Pentraxin-3 Levels in Patients with Stable Coronary Artery Disease after Drug-Eluting Stent Implantation |
| title_short | Prognostic Value of Plasma Pentraxin-3 Levels in Patients with Stable Coronary Artery Disease after Drug-Eluting Stent Implantation |
| title_sort | prognostic value of plasma pentraxin 3 levels in patients with stable coronary artery disease after drug eluting stent implantation |
| url | http://dx.doi.org/10.1155/2014/963096 |
| work_keys_str_mv | AT liuhaibo prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT guoxiaofang prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT wangchunming prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT yuanjie prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT chenguozhong prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT zhanglimei prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT caoyong prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT fangyu prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT baoyingchun prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT yuwangjun prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation AT gejunbo prognosticvalueofplasmapentraxin3levelsinpatientswithstablecoronaryarterydiseaseafterdrugelutingstentimplantation |