Francisella tularensis: FupA mutation contributes to fluoroquinolone resistance by increasing vesicle secretion and biofilm formation

Francisella tularensis: FupA mutation contributes to fluoroquinolone resistance by increasing vesicle secretion and biofilm formation

Francisella tularensis is the causative agent in tularemia for which the high prevalence of treatment failure and relapse is a major concern. Directed-evolution experiments revealed that acquisition of fluoroquinolone (FQ) resistance was linked to factors in addition to mutations in DNA gyrase. Here...

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Bibliographic Details
Main Authors: Claire Siebert, Helena Lindgren, Sabrina Ferré, Corinne Villers, Sandrine Boisset, Julien Perard, Anders Sjöstedt, Max Maurin, Céline Brochier-Armanet, Yohann Couté, Patricia Renesto
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Francisella
OMVs
biofilms
antibiotics
fluoroquinolones
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1615848
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https://www.tandfonline.com/doi/10.1080/22221751.2019.1615848

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