The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis
The purpose of this study was to clarify the role of pattern recognition receptors in Behçet’s disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by flow cytometry, and cytokine levels, interleukin...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/7539529 |
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| author | Bunsoon Choi Chang-Hee Suh Hyoun-Ah Kim Hasan M. Sayeed Seonghyang Sohn |
| author_facet | Bunsoon Choi Chang-Hee Suh Hyoun-Ah Kim Hasan M. Sayeed Seonghyang Sohn |
| author_sort | Bunsoon Choi |
| collection | DOAJ |
| description | The purpose of this study was to clarify the role of pattern recognition receptors in Behçet’s disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by flow cytometry, and cytokine levels, interleukin- (IL-) 18, IL-23, and IL-17A, were compared in plasma. The analysis was performed in active (n=13) and inactive (n=13) stages of BD patients. Rheumatoid arthritis patients (n=19), as a disease control, and healthy control (HC) (n=19) were enrolled. The frequencies of CD11b+ and CD32+ cells were significantly increased in active BD patients compared to HC. Disease severity score was correlated to CD11c+, CD206+, and CD209+ in whole leukocytes and CD11b+, CD11c+, CD206+, CD209+, and Dectin-1+ in granulocytes. The plasma levels of IL-17A were significantly different between HC and active BD. IL-18 showed significant difference between active and inactive BD patients. From this study, we concluded the expressions of several pattern recognition receptors were correlated to the joint symptoms of BD. |
| format | Article |
| id | doaj-art-041fa8ab631a491cae07fa87708b34c0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-041fa8ab631a491cae07fa87708b34c02025-02-03T06:01:39ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/75395297539529The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with ArthritisBunsoon Choi0Chang-Hee Suh1Hyoun-Ah Kim2Hasan M. Sayeed3Seonghyang Sohn4Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of KoreaDepartment of Rheumatology, Ajou University School of Medicine, Suwon, Republic of KoreaDepartment of Rheumatology, Ajou University School of Medicine, Suwon, Republic of KoreaDepartment of Biomedical Sciences, Ajou University School of Medicine, Suwon, Republic of KoreaDepartment of Microbiology, Ajou University School of Medicine, Suwon, Republic of KoreaThe purpose of this study was to clarify the role of pattern recognition receptors in Behçet’s disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by flow cytometry, and cytokine levels, interleukin- (IL-) 18, IL-23, and IL-17A, were compared in plasma. The analysis was performed in active (n=13) and inactive (n=13) stages of BD patients. Rheumatoid arthritis patients (n=19), as a disease control, and healthy control (HC) (n=19) were enrolled. The frequencies of CD11b+ and CD32+ cells were significantly increased in active BD patients compared to HC. Disease severity score was correlated to CD11c+, CD206+, and CD209+ in whole leukocytes and CD11b+, CD11c+, CD206+, CD209+, and Dectin-1+ in granulocytes. The plasma levels of IL-17A were significantly different between HC and active BD. IL-18 showed significant difference between active and inactive BD patients. From this study, we concluded the expressions of several pattern recognition receptors were correlated to the joint symptoms of BD.http://dx.doi.org/10.1155/2017/7539529 |
| spellingShingle | Bunsoon Choi Chang-Hee Suh Hyoun-Ah Kim Hasan M. Sayeed Seonghyang Sohn The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis Mediators of Inflammation |
| title | The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis |
| title_full | The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis |
| title_fullStr | The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis |
| title_full_unstemmed | The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis |
| title_short | The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis |
| title_sort | correlation of cd206 cd209 and disease severity in behcet s disease with arthritis |
| url | http://dx.doi.org/10.1155/2017/7539529 |
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