Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance
Summary: The pituitary gland is the central endocrine regulatory organ producing and releasing hormones that coordinate major body functions. The physical location of the pituitary gland at the base of the brain, though outside the protective blood-brain barrier, leads to an unexplored special immun...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112472401578X |
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| author | Henna Lehtonen Heli Jokela Julian Hofmann Lauriina Tola Arfa Mehmood Florent Ginhoux Burkhard Becher Melanie Greter Gennady G. Yegutkin Marko Salmi Heidi Gerke Pia Rantakari |
| author_facet | Henna Lehtonen Heli Jokela Julian Hofmann Lauriina Tola Arfa Mehmood Florent Ginhoux Burkhard Becher Melanie Greter Gennady G. Yegutkin Marko Salmi Heidi Gerke Pia Rantakari |
| author_sort | Henna Lehtonen |
| collection | DOAJ |
| description | Summary: The pituitary gland is the central endocrine regulatory organ producing and releasing hormones that coordinate major body functions. The physical location of the pituitary gland at the base of the brain, though outside the protective blood-brain barrier, leads to an unexplored special immune environment. Using single-cell transcriptomics, fate mapping, and imaging, we characterize pituitary-resident macrophages (pitMØs), revealing their heterogeneity and spatial specialization. Microglia-like macrophages (ml-MACs) are enriched in the posterior pituitary, while other pitMØs in the anterior pituitary exhibit close interactions with hormone-secreting cells. Importantly, all pitMØs originate from early yolk sac progenitors and maintain themselves through self-renewal, independent of bone marrow-derived monocytes. Macrophage depletion experiments unveil the role of macrophages in regulating intrapituitary hormonal balance through extracellular ATP-mediated intercellular signaling. Altogether, these findings provide information on pituitary gland macrophages and advance our understanding of immune-endocrine system crosstalk. |
| format | Article |
| id | doaj-art-041d3cb936bf46be82b1c3ee0f9a3cbb |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-041d3cb936bf46be82b1c3ee0f9a3cbb2025-01-23T05:26:37ZengElsevierCell Reports2211-12472025-02-01442115227Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balanceHenna Lehtonen0Heli Jokela1Julian Hofmann2Lauriina Tola3Arfa Mehmood4Florent Ginhoux5Burkhard Becher6Melanie Greter7Gennady G. Yegutkin8Marko Salmi9Heidi Gerke10Pia Rantakari11Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, FinlandInstitute of Biomedicine, University of Turku, 20520 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, FinlandShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648, Singapore; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France; Translational Immunology Institute, SingHealth Duke-NUS, Singapore 169856, Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeInstitute of Experimental Immunology, University of Zürich, 8057 Zurich, SwitzerlandInstitute of Experimental Immunology, University of Zürich, 8057 Zurich, SwitzerlandInFLAMES Research Flagship Center, University of Turku, 20520 Turku, Finland; MediCity Research Laboratory, University of Turku, 20520 Turku, FinlandInstitute of Biomedicine, University of Turku, 20520 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, Finland; MediCity Research Laboratory, University of Turku, 20520 Turku, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, Finland; Corresponding authorSummary: The pituitary gland is the central endocrine regulatory organ producing and releasing hormones that coordinate major body functions. The physical location of the pituitary gland at the base of the brain, though outside the protective blood-brain barrier, leads to an unexplored special immune environment. Using single-cell transcriptomics, fate mapping, and imaging, we characterize pituitary-resident macrophages (pitMØs), revealing their heterogeneity and spatial specialization. Microglia-like macrophages (ml-MACs) are enriched in the posterior pituitary, while other pitMØs in the anterior pituitary exhibit close interactions with hormone-secreting cells. Importantly, all pitMØs originate from early yolk sac progenitors and maintain themselves through self-renewal, independent of bone marrow-derived monocytes. Macrophage depletion experiments unveil the role of macrophages in regulating intrapituitary hormonal balance through extracellular ATP-mediated intercellular signaling. Altogether, these findings provide information on pituitary gland macrophages and advance our understanding of immune-endocrine system crosstalk.http://www.sciencedirect.com/science/article/pii/S221112472401578XCP: Immunology |
| spellingShingle | Henna Lehtonen Heli Jokela Julian Hofmann Lauriina Tola Arfa Mehmood Florent Ginhoux Burkhard Becher Melanie Greter Gennady G. Yegutkin Marko Salmi Heidi Gerke Pia Rantakari Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance Cell Reports CP: Immunology |
| title | Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance |
| title_full | Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance |
| title_fullStr | Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance |
| title_full_unstemmed | Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance |
| title_short | Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance |
| title_sort | early precursor derived pituitary gland tissue resident macrophages play a pivotal role in modulating hormonal balance |
| topic | CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S221112472401578X |
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