The Impact of Hematologic Disorders on the Severity of Cerebral Venous Sinus Thrombosis: A Comparative Study
Hematologic diseases are considered important contributors to cerebral venous sinus thrombosis (CVST) cases. This retrospective study aims to compare the difference of the clinical and radiological characters between CVST patients with and without hematologic diseases. Consecutive hospitalized CVST...
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| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296241309630 |
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| author | Mengqi Wang MD Xiangqian Huang MD Yuchuan Ding Ph.D Xunming Ji MD, PhD Ran Meng MD, PhD |
| author_facet | Mengqi Wang MD Xiangqian Huang MD Yuchuan Ding Ph.D Xunming Ji MD, PhD Ran Meng MD, PhD |
| author_sort | Mengqi Wang MD |
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| description | Hematologic diseases are considered important contributors to cerebral venous sinus thrombosis (CVST) cases. This retrospective study aims to compare the difference of the clinical and radiological characters between CVST patients with and without hematologic diseases. Consecutive hospitalized CVST patients with hematologic disorders constituted the hematologic disorder group, while that without identifiable risk factors comprised the control group in this study. We systematically documented the various types of hematologic diseases associated with CVST, along with laboratory tests. Clinical manifestations, imaging findings, as well as treatment and prognosis, were recorded. A comparative analysis was conducted between the hematologic disorder group and the control group based on the aforementioned parameters. The final analysis included 97 CVST cases associated with hematologic diseases and 65 cases without any identified risk factors. The spectrum of hematologic diseases in our study ranged from iron-deficiency anemia to acute leukemia. Patients with hematologic disorder showed higher admission mRS, greater thrombotic burden, and higher incidence of stroke and cerebral hemorrhage (p < 0.05). The use of batroxobin significantly improved the prognosis of CVST caused by hematologic diseases, without causing major bleeding or death during the follow-up period. Patients with hematologic disorders who develop CVST tend to present with more severe conditions compared to those without identifiable risk factors. It is essential to conduct timely screening for CVST in patients with hematologic diseases who present with risk factors of thrombosis. |
| format | Article |
| id | doaj-art-04156bd404d5475bbfa222f285f67590 |
| institution | Kabale University |
| issn | 1938-2723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-04156bd404d5475bbfa222f285f675902025-01-22T14:03:42ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232025-01-013110.1177/10760296241309630The Impact of Hematologic Disorders on the Severity of Cerebral Venous Sinus Thrombosis: A Comparative StudyMengqi Wang MD0Xiangqian Huang MD1Yuchuan Ding Ph.D2Xunming Ji MD, PhD3Ran Meng MD, PhD4 , Beijing, China Department of Neurosurgery, School of Medicine, Detroit, Michigan, USA Department of Neurosurgery, School of Medicine, Detroit, Michigan, USA , Beijing, China , Beijing, ChinaHematologic diseases are considered important contributors to cerebral venous sinus thrombosis (CVST) cases. This retrospective study aims to compare the difference of the clinical and radiological characters between CVST patients with and without hematologic diseases. Consecutive hospitalized CVST patients with hematologic disorders constituted the hematologic disorder group, while that without identifiable risk factors comprised the control group in this study. We systematically documented the various types of hematologic diseases associated with CVST, along with laboratory tests. Clinical manifestations, imaging findings, as well as treatment and prognosis, were recorded. A comparative analysis was conducted between the hematologic disorder group and the control group based on the aforementioned parameters. The final analysis included 97 CVST cases associated with hematologic diseases and 65 cases without any identified risk factors. The spectrum of hematologic diseases in our study ranged from iron-deficiency anemia to acute leukemia. Patients with hematologic disorder showed higher admission mRS, greater thrombotic burden, and higher incidence of stroke and cerebral hemorrhage (p < 0.05). The use of batroxobin significantly improved the prognosis of CVST caused by hematologic diseases, without causing major bleeding or death during the follow-up period. Patients with hematologic disorders who develop CVST tend to present with more severe conditions compared to those without identifiable risk factors. It is essential to conduct timely screening for CVST in patients with hematologic diseases who present with risk factors of thrombosis.https://doi.org/10.1177/10760296241309630 |
| spellingShingle | Mengqi Wang MD Xiangqian Huang MD Yuchuan Ding Ph.D Xunming Ji MD, PhD Ran Meng MD, PhD The Impact of Hematologic Disorders on the Severity of Cerebral Venous Sinus Thrombosis: A Comparative Study Clinical and Applied Thrombosis/Hemostasis |
| title | The Impact of Hematologic Disorders
on the Severity of Cerebral Venous Sinus Thrombosis: A Comparative Study |
| title_full | The Impact of Hematologic Disorders
on the Severity of Cerebral Venous Sinus Thrombosis: A Comparative Study |
| title_fullStr | The Impact of Hematologic Disorders
on the Severity of Cerebral Venous Sinus Thrombosis: A Comparative Study |
| title_full_unstemmed | The Impact of Hematologic Disorders
on the Severity of Cerebral Venous Sinus Thrombosis: A Comparative Study |
| title_short | The Impact of Hematologic Disorders
on the Severity of Cerebral Venous Sinus Thrombosis: A Comparative Study |
| title_sort | impact of hematologic disorders on the severity of cerebral venous sinus thrombosis a comparative study |
| url | https://doi.org/10.1177/10760296241309630 |
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