Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studies
Abstract Introduction Prostate cancer is one of the most common cancers in the United States with a high mortality rate. In recent years, the traditional opinion about prostate microbiome was challenged. Although there still are some arguments, an escalating number of researchers are shifting their...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-05937-7 |
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| author | Gui-Chen Ye Hao Peng Jia-Cheng Xiang Ling-Tao Miao Cheng-Zhi Liu Shao-Gang Wang Qi-Dong Xia |
| author_facet | Gui-Chen Ye Hao Peng Jia-Cheng Xiang Ling-Tao Miao Cheng-Zhi Liu Shao-Gang Wang Qi-Dong Xia |
| author_sort | Gui-Chen Ye |
| collection | DOAJ |
| description | Abstract Introduction Prostate cancer is one of the most common cancers in the United States with a high mortality rate. In recent years, the traditional opinion about prostate microbiome was challenged. Although there still are some arguments, an escalating number of researchers are shifting their focus toward the microbiome within the prostate tumor environment. Methods We mined the data of the microbiome extracted from the metagenome, and it offers a broader taxonomic coverage and accurate functional profiling. We used Kraken2, a mapping tool, to mine the gut microbiota of prostate cancer patients. A two-sample Mendelian Randomization was conducted to reflect the association between gut microbiome and cancer. Results In the study, we found the consistency of the special intratumor microbiome of both non-metastatic tumors and metastatic tumors. And we dig the gut microbiome in patients with different treatments. We found that some microbiotas may be associated with prostate cancer progression and a special microbiome in metastatic prostate cancer may exist. The anti-androgen therapy can significantly change both the intratumor and gut microbiome. Conclusion With the progression and metastasis of prostate cancer, some intratumor microbiome changes. And anti-androgen influences both the intratumor and gut microbiome. Our discovery may help researchers further understand the progression, metastasis, and resistance of prostate cancer from the perspective of microbiome level. |
| format | Article |
| id | doaj-art-04151dcf0081459c818c70ee2a1d6a25 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-04151dcf0081459c818c70ee2a1d6a252025-02-02T12:40:24ZengBMCJournal of Translational Medicine1479-58762025-01-0123111210.1186/s12967-024-05937-7Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studiesGui-Chen Ye0Hao Peng1Jia-Cheng Xiang2Ling-Tao Miao3Cheng-Zhi Liu4Shao-Gang Wang5Qi-Dong Xia6Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyTongji Medical College, Huazhong University of Science and TechnologyDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Introduction Prostate cancer is one of the most common cancers in the United States with a high mortality rate. In recent years, the traditional opinion about prostate microbiome was challenged. Although there still are some arguments, an escalating number of researchers are shifting their focus toward the microbiome within the prostate tumor environment. Methods We mined the data of the microbiome extracted from the metagenome, and it offers a broader taxonomic coverage and accurate functional profiling. We used Kraken2, a mapping tool, to mine the gut microbiota of prostate cancer patients. A two-sample Mendelian Randomization was conducted to reflect the association between gut microbiome and cancer. Results In the study, we found the consistency of the special intratumor microbiome of both non-metastatic tumors and metastatic tumors. And we dig the gut microbiome in patients with different treatments. We found that some microbiotas may be associated with prostate cancer progression and a special microbiome in metastatic prostate cancer may exist. The anti-androgen therapy can significantly change both the intratumor and gut microbiome. Conclusion With the progression and metastasis of prostate cancer, some intratumor microbiome changes. And anti-androgen influences both the intratumor and gut microbiome. Our discovery may help researchers further understand the progression, metastasis, and resistance of prostate cancer from the perspective of microbiome level.https://doi.org/10.1186/s12967-024-05937-7Prostate cancerMicrobiomeGutTreatmentAndrogen |
| spellingShingle | Gui-Chen Ye Hao Peng Jia-Cheng Xiang Ling-Tao Miao Cheng-Zhi Liu Shao-Gang Wang Qi-Dong Xia Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studies Journal of Translational Medicine Prostate cancer Microbiome Gut Treatment Androgen |
| title | Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studies |
| title_full | Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studies |
| title_fullStr | Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studies |
| title_full_unstemmed | Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studies |
| title_short | Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studies |
| title_sort | comprehensive analysis of the interaction microbiome and prostate cancer an initial exploration from multi cohort metagenome and gwas studies |
| topic | Prostate cancer Microbiome Gut Treatment Androgen |
| url | https://doi.org/10.1186/s12967-024-05937-7 |
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