Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance
We report the finding of alkaline phosphatase-immunoglobulin complex (macro-alkaline phosphatase (macro-ALP)) in a patient with persistently increased ALP activity. The identification of macro-ALP is important to rule out pathological causes of increased ALP activity and to avoid unnecessary diagnos...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8406971 |
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| _version_ | 1832550394367049728 |
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| author | I. Ramasamy |
| author_facet | I. Ramasamy |
| author_sort | I. Ramasamy |
| collection | DOAJ |
| description | We report the finding of alkaline phosphatase-immunoglobulin complex (macro-alkaline phosphatase (macro-ALP)) in a patient with persistently increased ALP activity. The identification of macro-ALP is important to rule out pathological causes of increased ALP activity and to avoid unnecessary diagnostic investigation. The patient was subsequently diagnosed with vitamin D deficiency, gallstone pancreatitis, and monoclonal gammopathy of undefined significance (MGUS). Macro-ALP can coexist with disease that can increase serum ALP activity. We report, for the first time, a case of macro-ALP in a patient with a monoclonal protein (M-protein). |
| format | Article |
| id | doaj-art-040dd9ee61794f749ac516688b96c5fc |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-040dd9ee61794f749ac516688b96c5fc2025-02-03T06:06:43ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/84069718406971Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined SignificanceI. Ramasamy0Worcester Royal Hospital, Charles Hastings Way, Worcester WR41DD, UKWe report the finding of alkaline phosphatase-immunoglobulin complex (macro-alkaline phosphatase (macro-ALP)) in a patient with persistently increased ALP activity. The identification of macro-ALP is important to rule out pathological causes of increased ALP activity and to avoid unnecessary diagnostic investigation. The patient was subsequently diagnosed with vitamin D deficiency, gallstone pancreatitis, and monoclonal gammopathy of undefined significance (MGUS). Macro-ALP can coexist with disease that can increase serum ALP activity. We report, for the first time, a case of macro-ALP in a patient with a monoclonal protein (M-protein).http://dx.doi.org/10.1155/2020/8406971 |
| spellingShingle | I. Ramasamy Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance Case Reports in Hematology |
| title | Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance |
| title_full | Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance |
| title_fullStr | Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance |
| title_full_unstemmed | Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance |
| title_short | Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance |
| title_sort | persistent increase in serum alkaline phosphatase in a patient with monoclonal gammopathy of undefined significance |
| url | http://dx.doi.org/10.1155/2020/8406971 |
| work_keys_str_mv | AT iramasamy persistentincreaseinserumalkalinephosphataseinapatientwithmonoclonalgammopathyofundefinedsignificance |