Macular Amyloidosis and Epstein-Barr Virus
Background. Amyloidosis is extracellular precipitation of eosinophilic hyaline material of self-origin with special staining features and fibrillar ultrastructure. Macular amyloidosis is limited to the skin, and several factors have been proposed for its pathogenesis. Detection of Epstein-Barr virus...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/6089102 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561194318168064 |
|---|---|
| author | Yalda Nahidi Naser Tayyebi Meibodi Zahra Meshkat Narges Nazeri |
| author_facet | Yalda Nahidi Naser Tayyebi Meibodi Zahra Meshkat Narges Nazeri |
| author_sort | Yalda Nahidi |
| collection | DOAJ |
| description | Background. Amyloidosis is extracellular precipitation of eosinophilic hyaline material of self-origin with special staining features and fibrillar ultrastructure. Macular amyloidosis is limited to the skin, and several factors have been proposed for its pathogenesis. Detection of Epstein-Barr virus (EBV) DNA in this lesion suggests that this virus can play a role in pathogenesis of this disease. Objective. EBV DNA detection was done on 30 skin samples with a diagnosis of macular amyloidosis and 31 healthy skin samples in the margin of removed melanocytic nevi by using PCR. Results. In patients positive for beta-globin gene in PCR, BLLF1 gene of EBV virus was positive in 23 patients (8 patients in case and 15 patients in the control group). There was no significant difference in presence of EBV DNA between macular amyloidosis (3.8%) and control (23.8%) groups (P=0.08). Conclusion. The findings of this study showed that EBV is not involved in pathogenesis of macular amyloidosis. |
| format | Article |
| id | doaj-art-040dbe83058246f3926c9707c4d507c7 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-040dbe83058246f3926c9707c4d507c72025-02-03T01:25:34ZengWileyDermatology Research and Practice1687-61051687-61132016-01-01201610.1155/2016/60891026089102Macular Amyloidosis and Epstein-Barr VirusYalda Nahidi0Naser Tayyebi Meibodi1Zahra Meshkat2Narges Nazeri3Skin Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9176699199, IranSkin Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9176699199, IranVirology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9176699199, IranPathology Department of Mashhad University of Medical Sciences, Mashhad 9176699199, IranBackground. Amyloidosis is extracellular precipitation of eosinophilic hyaline material of self-origin with special staining features and fibrillar ultrastructure. Macular amyloidosis is limited to the skin, and several factors have been proposed for its pathogenesis. Detection of Epstein-Barr virus (EBV) DNA in this lesion suggests that this virus can play a role in pathogenesis of this disease. Objective. EBV DNA detection was done on 30 skin samples with a diagnosis of macular amyloidosis and 31 healthy skin samples in the margin of removed melanocytic nevi by using PCR. Results. In patients positive for beta-globin gene in PCR, BLLF1 gene of EBV virus was positive in 23 patients (8 patients in case and 15 patients in the control group). There was no significant difference in presence of EBV DNA between macular amyloidosis (3.8%) and control (23.8%) groups (P=0.08). Conclusion. The findings of this study showed that EBV is not involved in pathogenesis of macular amyloidosis.http://dx.doi.org/10.1155/2016/6089102 |
| spellingShingle | Yalda Nahidi Naser Tayyebi Meibodi Zahra Meshkat Narges Nazeri Macular Amyloidosis and Epstein-Barr Virus Dermatology Research and Practice |
| title | Macular Amyloidosis and Epstein-Barr Virus |
| title_full | Macular Amyloidosis and Epstein-Barr Virus |
| title_fullStr | Macular Amyloidosis and Epstein-Barr Virus |
| title_full_unstemmed | Macular Amyloidosis and Epstein-Barr Virus |
| title_short | Macular Amyloidosis and Epstein-Barr Virus |
| title_sort | macular amyloidosis and epstein barr virus |
| url | http://dx.doi.org/10.1155/2016/6089102 |
| work_keys_str_mv | AT yaldanahidi macularamyloidosisandepsteinbarrvirus AT nasertayyebimeibodi macularamyloidosisandepsteinbarrvirus AT zahrameshkat macularamyloidosisandepsteinbarrvirus AT nargesnazeri macularamyloidosisandepsteinbarrvirus |