Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation 
in the Development and Immune Escape of Non-small Cell Lung Cancer

Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation 
in the Development and Immune Escape of Non-small Cell Lung Cancer

Non-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (...

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Bibliographic Details
Main Authors: Wangcheng CHEN, Lili PANG, Yuemei LAN, Yanhong SHI, Bingbing WEN, Baihong ZHANG
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2025-04-01
Series:Chinese Journal of Lung Cancer
Subjects:
lung neoplasms
zdhhc enzymes
protein palmitoylation
immune escape
pd-l1
Online Access:http://dx.doi.org/10.3779/j.issn.1009-3419.2025.102.15
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Summary:Non-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (PTM) primarily catalyzed by palmitoyltransferases of the zinc finger DHHC-type (ZDHHC), has recently demonstrated important implications in NSCLC. This review aims to elucidate the mechanisms and clinical potential of ZDHHC-mediated protein palmitoylation in NSCLC progression and immune escape.
ISSN:1009-3419
1999-6187

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