The effects of chemogenetic targeting of serotonin-projecting pathways on L-DOPA-induced dyskinesia and psychosis in a bilateral rat model of Parkinson’s disease

The effects of chemogenetic targeting of serotonin-projecting pathways on L-DOPA-induced dyskinesia and psychosis in a bilateral rat model of Parkinson’s disease

IntroductionParkinson’s disease (PD) is commonly characterized by severe dopamine (DA) depletion within the substantia nigra (SN) leading to a myriad of motor and non-motor symptoms. One underappreciated and prevalent non-motor symptom, Parkinson’s disease-associated psychosis (PDAP), significantly...

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Bibliographic Details
Main Authors: Natalie Lipari, Ashley Galfano, Shruti Venkatesh, Han Grezenko, Ivette M. Sandoval, Fredric P. Manfredsson, Christopher Bishop
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Neural Circuits
Subjects:
PDAP
DREADDs
5-HT
LID
bilateral
PD
Online Access:https://www.frontiersin.org/articles/10.3389/fncir.2024.1463941/full
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