Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives
Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. Meanwhile, researchers around the world are still exploring...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/435713 |
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| _version_ | 1832555508973699072 |
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| author | Chenchen Shi Haipeng Li Yifu Yang Lifei Hou |
| author_facet | Chenchen Shi Haipeng Li Yifu Yang Lifei Hou |
| author_sort | Chenchen Shi |
| collection | DOAJ |
| description | Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. Meanwhile, researchers around the world are still exploring the unknown bioactivities of artemisinin derivatives. In this review, we provide a comprehensive discussion on recent advances of artemisinin derivatives affecting inflammation and autoimmunity, the underlying molecular mechanisms, and also drug development of artemisinins beyond antimalarial functions. |
| format | Article |
| id | doaj-art-03e35b1eaf0148f180ccd1be4433181b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-03e35b1eaf0148f180ccd1be4433181b2025-02-03T05:47:57ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/435713435713Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its DerivativesChenchen Shi0Haipeng Li1Yifu Yang2Lifei Hou3Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Orthopedics, Beijing Army General Hospital, Beijing, ChinaLaboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaProgram in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USAArtemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. Meanwhile, researchers around the world are still exploring the unknown bioactivities of artemisinin derivatives. In this review, we provide a comprehensive discussion on recent advances of artemisinin derivatives affecting inflammation and autoimmunity, the underlying molecular mechanisms, and also drug development of artemisinins beyond antimalarial functions.http://dx.doi.org/10.1155/2015/435713 |
| spellingShingle | Chenchen Shi Haipeng Li Yifu Yang Lifei Hou Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives Mediators of Inflammation |
| title | Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives |
| title_full | Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives |
| title_fullStr | Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives |
| title_full_unstemmed | Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives |
| title_short | Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives |
| title_sort | anti inflammatory and immunoregulatory functions of artemisinin and its derivatives |
| url | http://dx.doi.org/10.1155/2015/435713 |
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