Modeling the potential impact of rectal microbicides to reduce HIV transmission in bathhouses
We evaluate the potential impact of rectal microbicides for reducing HIVtransmission in bathhouses. A new mathematical model describing HIV transmissiondynamics among men who have sex with men (MSM) in bathhouses is constructed and analyzed.The model incorporates key features affecting transmission...
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| Format: | Article |
| Language: | English |
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AIMS Press
2006-04-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2006.3.459 |
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| author | Romulus Breban Ian McGowan Chad Topaz Elissa J. Schwartz Peter Anton Sally Blower |
| author_facet | Romulus Breban Ian McGowan Chad Topaz Elissa J. Schwartz Peter Anton Sally Blower |
| author_sort | Romulus Breban |
| collection | DOAJ |
| description | We evaluate the potential impact of rectal microbicides for reducing HIVtransmission in bathhouses. A new mathematical model describing HIV transmissiondynamics among men who have sex with men (MSM) in bathhouses is constructed and analyzed.The model incorporates key features affecting transmission, including sexual rolebehavior (insertive and receptive anal intercourse acts), biological transmissibilityof HIV, frequency and efficacy of condom usage, and, most pertinently, frequency andefficacy of rectal microbicide usage. To evaluate the potential impact of rectalmicrobicide usage, we quantify the effect of rectal microbicides (ranging in efficacyfrom 10% to 90%) on reducing the number of HIV infections in the bathhouse.We conduct uncertainty analyses to assess the effect of variability in both biologicaland behavioral parameters. We find that even moderately effective rectalmicrobicides (if used in 10% to 50% of the sex acts) would substantially reducetransmission in bathhouses. For example, a 50% effective rectal microbicide (usedin 50% of sex acts) would reduce the number of secondary infections by almost 13% atdisease invasion. Our modeling analyses show that even moderately effective rectalmicrobicides could be very effective prevention tools for reducing transmission inbathhouses and also potentially limit the spread of HIV in the community. |
| format | Article |
| id | doaj-art-03e21b73d02a4395a88e99fcafce9877 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2006-04-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-03e21b73d02a4395a88e99fcafce98772025-01-24T01:51:49ZengAIMS PressMathematical Biosciences and Engineering1551-00182006-04-013345946610.3934/mbe.2006.3.459Modeling the potential impact of rectal microbicides to reduce HIV transmission in bathhousesRomulus Breban0Ian McGowan1Chad Topaz2Elissa J. Schwartz3Peter Anton4Sally Blower5Department of Biomathematics, David Ge®en School of Medicine at UCLA, Los Angeles, California, 90024Department of Biomathematics, David Ge®en School of Medicine at UCLA, Los Angeles, California, 90024Department of Biomathematics, David Ge®en School of Medicine at UCLA, Los Angeles, California, 90024Department of Biomathematics, David Ge®en School of Medicine at UCLA, Los Angeles, California, 90024Department of Biomathematics, David Ge®en School of Medicine at UCLA, Los Angeles, California, 90024Department of Biomathematics, David Ge®en School of Medicine at UCLA, Los Angeles, California, 90024We evaluate the potential impact of rectal microbicides for reducing HIVtransmission in bathhouses. A new mathematical model describing HIV transmissiondynamics among men who have sex with men (MSM) in bathhouses is constructed and analyzed.The model incorporates key features affecting transmission, including sexual rolebehavior (insertive and receptive anal intercourse acts), biological transmissibilityof HIV, frequency and efficacy of condom usage, and, most pertinently, frequency andefficacy of rectal microbicide usage. To evaluate the potential impact of rectalmicrobicide usage, we quantify the effect of rectal microbicides (ranging in efficacyfrom 10% to 90%) on reducing the number of HIV infections in the bathhouse.We conduct uncertainty analyses to assess the effect of variability in both biologicaland behavioral parameters. We find that even moderately effective rectalmicrobicides (if used in 10% to 50% of the sex acts) would substantially reducetransmission in bathhouses. For example, a 50% effective rectal microbicide (usedin 50% of sex acts) would reduce the number of secondary infections by almost 13% atdisease invasion. Our modeling analyses show that even moderately effective rectalmicrobicides could be very effective prevention tools for reducing transmission inbathhouses and also potentially limit the spread of HIV in the community.https://www.aimspress.com/article/doi/10.3934/mbe.2006.3.459hiv-1bathhousemsm.transmissionmathematical modelrectal microbicideanal intercourse |
| spellingShingle | Romulus Breban Ian McGowan Chad Topaz Elissa J. Schwartz Peter Anton Sally Blower Modeling the potential impact of rectal microbicides to reduce HIV transmission in bathhouses Mathematical Biosciences and Engineering hiv-1 bathhouse msm. transmission mathematical model rectal microbicide anal intercourse |
| title | Modeling the potential impact of rectal microbicides to reduce HIV transmission in bathhouses |
| title_full | Modeling the potential impact of rectal microbicides to reduce HIV transmission in bathhouses |
| title_fullStr | Modeling the potential impact of rectal microbicides to reduce HIV transmission in bathhouses |
| title_full_unstemmed | Modeling the potential impact of rectal microbicides to reduce HIV transmission in bathhouses |
| title_short | Modeling the potential impact of rectal microbicides to reduce HIV transmission in bathhouses |
| title_sort | modeling the potential impact of rectal microbicides to reduce hiv transmission in bathhouses |
| topic | hiv-1 bathhouse msm. transmission mathematical model rectal microbicide anal intercourse |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2006.3.459 |
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