Anti-Müllerian Hormone as a Sensitive Marker of Ovarian Function in Young Cancer Survivors
We evaluated ovarian function by measuring the levels of anti-Müllerian hormone (AMH), estradiol, and gonadotropins in 83 young women treated for cancer during childhood and adolescence, and classified according to post-treatment gonadal toxicity versus 38 healthy females. Results. The mean AMH valu...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/125080 |
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| author | Maryna Krawczuk-Rybak Elzbieta Leszczynska Marta Poznanska Beata Zelazowska-Rutkowska Jolanta Wysocka |
| author_facet | Maryna Krawczuk-Rybak Elzbieta Leszczynska Marta Poznanska Beata Zelazowska-Rutkowska Jolanta Wysocka |
| author_sort | Maryna Krawczuk-Rybak |
| collection | DOAJ |
| description | We evaluated ovarian function by measuring the levels of anti-Müllerian hormone (AMH), estradiol, and gonadotropins in 83 young women treated for cancer during childhood and adolescence, and classified according to post-treatment gonadal toxicity versus 38 healthy females. Results. The mean AMH values were lower in the entire cohort independently of the risk group as compared to the control, whereas FSH was elevated only in the high risk group. The lowest AMH values were noted in patients after bone marrow transplantation (BMT) and those treated for Hodgkin lymphoma (HL). Nineteen patients (22.9%) had elevated FSH. They all had low AMH values. Lowered AMH values (but with normal FSH and LH) were observed in 43 patients (51.8%). There was no effect of age at the time of treatment (before puberty, during or after puberty) on AMH levels. Conclusion. Our results show the utility of AMH measurement as a sensitive marker of a reduced ovarian reserve in young cancer survivors. Patients after BMT and patients treated for HL, independently of age at treatment (prepuberty or puberty), are at the highest risk of gonadal damage and early menopause. |
| format | Article |
| id | doaj-art-03d7698e31a24041b4836faab2991374 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-03d7698e31a24041b4836faab29913742025-02-03T01:00:57ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/125080125080Anti-Müllerian Hormone as a Sensitive Marker of Ovarian Function in Young Cancer SurvivorsMaryna Krawczuk-Rybak0Elzbieta Leszczynska1Marta Poznanska2Beata Zelazowska-Rutkowska3Jolanta Wysocka4Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Waszyngtona 17, 15-274 Bialystok, PolandDepartment of Pediatric Oncology and Hematology, Medical University of Bialystok, Waszyngtona 17, 15-274 Bialystok, PolandDepartment of Pediatric Oncology and Hematology, Medical University of Bialystok, Waszyngtona 17, 15-274 Bialystok, PolandDepartment of Pediatric Laboratory Diagnostics, Medical University of Bialystok, PolandDepartment of Pediatric Laboratory Diagnostics, Medical University of Bialystok, PolandWe evaluated ovarian function by measuring the levels of anti-Müllerian hormone (AMH), estradiol, and gonadotropins in 83 young women treated for cancer during childhood and adolescence, and classified according to post-treatment gonadal toxicity versus 38 healthy females. Results. The mean AMH values were lower in the entire cohort independently of the risk group as compared to the control, whereas FSH was elevated only in the high risk group. The lowest AMH values were noted in patients after bone marrow transplantation (BMT) and those treated for Hodgkin lymphoma (HL). Nineteen patients (22.9%) had elevated FSH. They all had low AMH values. Lowered AMH values (but with normal FSH and LH) were observed in 43 patients (51.8%). There was no effect of age at the time of treatment (before puberty, during or after puberty) on AMH levels. Conclusion. Our results show the utility of AMH measurement as a sensitive marker of a reduced ovarian reserve in young cancer survivors. Patients after BMT and patients treated for HL, independently of age at treatment (prepuberty or puberty), are at the highest risk of gonadal damage and early menopause.http://dx.doi.org/10.1155/2013/125080 |
| spellingShingle | Maryna Krawczuk-Rybak Elzbieta Leszczynska Marta Poznanska Beata Zelazowska-Rutkowska Jolanta Wysocka Anti-Müllerian Hormone as a Sensitive Marker of Ovarian Function in Young Cancer Survivors International Journal of Endocrinology |
| title | Anti-Müllerian Hormone as a Sensitive Marker of Ovarian Function in Young Cancer Survivors |
| title_full | Anti-Müllerian Hormone as a Sensitive Marker of Ovarian Function in Young Cancer Survivors |
| title_fullStr | Anti-Müllerian Hormone as a Sensitive Marker of Ovarian Function in Young Cancer Survivors |
| title_full_unstemmed | Anti-Müllerian Hormone as a Sensitive Marker of Ovarian Function in Young Cancer Survivors |
| title_short | Anti-Müllerian Hormone as a Sensitive Marker of Ovarian Function in Young Cancer Survivors |
| title_sort | anti mullerian hormone as a sensitive marker of ovarian function in young cancer survivors |
| url | http://dx.doi.org/10.1155/2013/125080 |
| work_keys_str_mv | AT marynakrawczukrybak antimullerianhormoneasasensitivemarkerofovarianfunctioninyoungcancersurvivors AT elzbietaleszczynska antimullerianhormoneasasensitivemarkerofovarianfunctioninyoungcancersurvivors AT martapoznanska antimullerianhormoneasasensitivemarkerofovarianfunctioninyoungcancersurvivors AT beatazelazowskarutkowska antimullerianhormoneasasensitivemarkerofovarianfunctioninyoungcancersurvivors AT jolantawysocka antimullerianhormoneasasensitivemarkerofovarianfunctioninyoungcancersurvivors |