Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders
Hemophilia poses distinct challenges to wound healing, primarily due to uncontrolled bleeding and delayed tissue repair. This study explored a novel tannic acid-thioctic acid (TATA) hydrogel, enriched with exosomes derived from bone marrow mesenchymal stem cells, as a therapeutic strategy for enhanc...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000547 |
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| author | Yuesheng Tu Weixin Zheng Zichu Ding Jie Xiang Qinfeng Yang Yuchen Liu Jue Cao Yuling Shen Zinan Tang Shen Lin Lei Fan Yaowen Xu Bin Chen |
| author_facet | Yuesheng Tu Weixin Zheng Zichu Ding Jie Xiang Qinfeng Yang Yuchen Liu Jue Cao Yuling Shen Zinan Tang Shen Lin Lei Fan Yaowen Xu Bin Chen |
| author_sort | Yuesheng Tu |
| collection | DOAJ |
| description | Hemophilia poses distinct challenges to wound healing, primarily due to uncontrolled bleeding and delayed tissue repair. This study explored a novel tannic acid-thioctic acid (TATA) hydrogel, enriched with exosomes derived from bone marrow mesenchymal stem cells, as a therapeutic strategy for enhancing skin wound healing in a hemophilia model. The hydrogel exhibited robust hemostatic efficacy, potent antioxidant activity, and the capacity to modulate the inflammatory microenvironment. Both in vitro and in vivo assessments demonstrated significantly accelerated wound closure, increased collagen deposition, and pronounced angiogenesis in the TATA Hydrogel-Exosome(TATA Hydrogel-Exos) treatment group relative to controls. Rheological evaluations confirmed the self-healing properties and mechanical durability, of the hydrogel, underscoring its potential for sustained therapeutic application. Importantly, no significant systemic toxicity was observed, indicating favorable biocompatibility. These multifunctional TATA Hydrogel-Exos present a promising therapeutic avenue for hemophilia-related wounds by integrating hemostasis, inflammation regulation, and tissue regeneration. |
| format | Article |
| id | doaj-art-03b841ae8ab345538ecfc2740ec65402 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-03b841ae8ab345538ecfc2740ec654022025-02-05T04:32:34ZengElsevierMaterials Today Bio2590-00642025-04-0131101496Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disordersYuesheng Tu0Weixin Zheng1Zichu Ding2Jie Xiang3Qinfeng Yang4Yuchen Liu5Jue Cao6Yuling Shen7Zinan Tang8Shen Lin9Lei Fan10Yaowen Xu11Bin Chen12Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, ChinaDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, ChinaDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, ChinaDepartment of Orthopaedics and Traumatology, The First Affiliated Hospital, Hengyang Medical School, University of South China, ChinaDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, ChinaDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, ChinaDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, ChinaDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, ChinaDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, ChinaDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Corresponding author.Department of Health Management, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China; Corresponding author.Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China; Corresponding author.Hemophilia poses distinct challenges to wound healing, primarily due to uncontrolled bleeding and delayed tissue repair. This study explored a novel tannic acid-thioctic acid (TATA) hydrogel, enriched with exosomes derived from bone marrow mesenchymal stem cells, as a therapeutic strategy for enhancing skin wound healing in a hemophilia model. The hydrogel exhibited robust hemostatic efficacy, potent antioxidant activity, and the capacity to modulate the inflammatory microenvironment. Both in vitro and in vivo assessments demonstrated significantly accelerated wound closure, increased collagen deposition, and pronounced angiogenesis in the TATA Hydrogel-Exosome(TATA Hydrogel-Exos) treatment group relative to controls. Rheological evaluations confirmed the self-healing properties and mechanical durability, of the hydrogel, underscoring its potential for sustained therapeutic application. Importantly, no significant systemic toxicity was observed, indicating favorable biocompatibility. These multifunctional TATA Hydrogel-Exos present a promising therapeutic avenue for hemophilia-related wounds by integrating hemostasis, inflammation regulation, and tissue regeneration.http://www.sciencedirect.com/science/article/pii/S2590006425000547HydrogelExosomeWound healingDeliveryInflammation |
| spellingShingle | Yuesheng Tu Weixin Zheng Zichu Ding Jie Xiang Qinfeng Yang Yuchen Liu Jue Cao Yuling Shen Zinan Tang Shen Lin Lei Fan Yaowen Xu Bin Chen Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders Materials Today Bio Hydrogel Exosome Wound healing Delivery Inflammation |
| title | Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders |
| title_full | Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders |
| title_fullStr | Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders |
| title_full_unstemmed | Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders |
| title_short | Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders |
| title_sort | exosome loaded tannic acid thioctic acid hydrogel enhances wound healing in coagulation disorders |
| topic | Hydrogel Exosome Wound healing Delivery Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000547 |
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