Fixed dose combination dextromethorphan-bupropion: A hope for treatment resistant depression (TRD)
Background: Treatment resistant depression (TRD) has been identified as non-response to depression with adequate dose and trial of two antidepressant medications of different classes. Near about 30% depressive patients are TRD cases. Olanzapine‐fluoxetine combination, rTMS, Intravenous ketamine and...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry_315_25 |
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| Summary: | Background:
Treatment resistant depression (TRD) has been identified as non-response to depression with adequate dose and trial of two antidepressant medications of different classes. Near about 30% depressive patients are TRD cases. Olanzapine‐fluoxetine combination, rTMS, Intravenous ketamine and Electroconvulsive therapy have been till now studied in TRD. Dextromethorphan-bupropion is a newer antidepressant, which has been found to be effective, fast-acting, and well tolerated medicine for depression.
Cases and conclusion:
We used this novel antidepressant in three cases of TRD, alone and with combination, and it showed satisfactory response within 2 weeks. |
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| ISSN: | 0019-5545 1998-3794 |