Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder
Aim. Recent research implicated place of an immune mechanism in the pathophysiology of obsessive-compulsive disorder (OCD). Despite increasing evidence involvement of cytokine release in OCD, results of the studies are inconsistent. The aim of this study was to evaluate the plasma levels of the cyt...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/65704 |
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| author | N. Konuk I. O. Tekın U. Ozturk L. Atik N. Atasoy S. Bektas A. Erdogan |
| author_facet | N. Konuk I. O. Tekın U. Ozturk L. Atik N. Atasoy S. Bektas A. Erdogan |
| author_sort | N. Konuk |
| collection | DOAJ |
| description | Aim. Recent research implicated place of an immune mechanism in the pathophysiology of obsessive-compulsive disorder (OCD). Despite increasing evidence involvement of cytokine release in OCD, results of the studies are inconsistent. The aim of this study was to evaluate the plasma levels of the cytokines; tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in OCD patients. Methods. Plasma concentrations of TNF-α and IL-6 were measured in 31 drug-free outpatients with OCD, and 31-year age and sex-matched healthy controls. TNF-α and IL-6 concentrations in blood were determined by enzyme-linked immunosorbent assay (ELISA). Results. Both TNF-α and IL-6 levels showed statistically significant increases in OCD patients compared to controls (P<.000, P<.001, resp.). In addition, the age of onset was negatively correlated with TNF-α level (r=−.402, P=.025) and duration of illness was weakly correlated with IL-6 levels (r:.357; P:.048) in patients group. Conclusion. OCD patients showed increases in TNF-α and IL-6 levels compared to the healthy controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of OCD. |
| format | Article |
| id | doaj-art-03a1ee0b81434beaab6b5a6cc67c669f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-03a1ee0b81434beaab6b5a6cc67c669f2025-02-03T01:01:49ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/6570465704Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive DisorderN. Konuk0I. O. Tekın1U. Ozturk2L. Atik3N. Atasoy4S. Bektas5A. Erdogan6Department of Psychiatry, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Immunology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Psychiatry, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Psychiatry, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Psychiatry, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Pathology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Psychiatry, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyAim. Recent research implicated place of an immune mechanism in the pathophysiology of obsessive-compulsive disorder (OCD). Despite increasing evidence involvement of cytokine release in OCD, results of the studies are inconsistent. The aim of this study was to evaluate the plasma levels of the cytokines; tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in OCD patients. Methods. Plasma concentrations of TNF-α and IL-6 were measured in 31 drug-free outpatients with OCD, and 31-year age and sex-matched healthy controls. TNF-α and IL-6 concentrations in blood were determined by enzyme-linked immunosorbent assay (ELISA). Results. Both TNF-α and IL-6 levels showed statistically significant increases in OCD patients compared to controls (P<.000, P<.001, resp.). In addition, the age of onset was negatively correlated with TNF-α level (r=−.402, P=.025) and duration of illness was weakly correlated with IL-6 levels (r:.357; P:.048) in patients group. Conclusion. OCD patients showed increases in TNF-α and IL-6 levels compared to the healthy controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of OCD.http://dx.doi.org/10.1155/2007/65704 |
| spellingShingle | N. Konuk I. O. Tekın U. Ozturk L. Atik N. Atasoy S. Bektas A. Erdogan Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder Mediators of Inflammation |
| title | Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder |
| title_full | Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder |
| title_fullStr | Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder |
| title_full_unstemmed | Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder |
| title_short | Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder |
| title_sort | plasma levels of tumor necrosis factor alpha and interleukin 6 in obsessive compulsive disorder |
| url | http://dx.doi.org/10.1155/2007/65704 |
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