Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi Explants
Congenital Chagas disease, a neglected tropical disease, endemic in Latin America, is associated with premature labor and miscarriage. During vertical transmission the parasite Trypanosoma cruzi (T. cruzi) crosses the placental barrier. However, the exact mechanism of the placental infection remains...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/614820 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551019965317120 |
|---|---|
| author | Ricardo E. Fretes Ulrike Kemmerling |
| author_facet | Ricardo E. Fretes Ulrike Kemmerling |
| author_sort | Ricardo E. Fretes |
| collection | DOAJ |
| description | Congenital Chagas disease, a neglected tropical disease, endemic in Latin America, is associated with premature labor and miscarriage. During vertical transmission the parasite Trypanosoma cruzi (T. cruzi) crosses the placental barrier. However, the exact mechanism of the placental infection remains unclear. We review the congenital transmission of T. cruzi, particularly the role of possible local placental factors that contribute to the vertical transmission of the parasite. Additionally, we analyze the different methods available for studying the congenital transmission of the parasite. In that context, the ex vivo infection with T. cruzi trypomastigotes of human placental chorionic villi constitutes an excellent tool for studying parasite infection strategies as well as possible local antiparasitic mechanisms. |
| format | Article |
| id | doaj-art-03977421a66b40799c8aa183ddb3c499 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-03977421a66b40799c8aa183ddb3c4992025-02-03T06:05:09ZengWileyJournal of Tropical Medicine1687-96861687-96942012-01-01201210.1155/2012/614820614820Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi ExplantsRicardo E. Fretes0Ulrike Kemmerling1Department of Histology and Embryology, Faculty of Medicine, Universidad Nacional Córdoba, 5000 Cordoba, ArgentinaProgram of Anatomy and Developmental Biology, Institute for Biomedical Sciences, Faculty of Medicine, University of Chile, 8380453 Santiago, ChileCongenital Chagas disease, a neglected tropical disease, endemic in Latin America, is associated with premature labor and miscarriage. During vertical transmission the parasite Trypanosoma cruzi (T. cruzi) crosses the placental barrier. However, the exact mechanism of the placental infection remains unclear. We review the congenital transmission of T. cruzi, particularly the role of possible local placental factors that contribute to the vertical transmission of the parasite. Additionally, we analyze the different methods available for studying the congenital transmission of the parasite. In that context, the ex vivo infection with T. cruzi trypomastigotes of human placental chorionic villi constitutes an excellent tool for studying parasite infection strategies as well as possible local antiparasitic mechanisms.http://dx.doi.org/10.1155/2012/614820 |
| spellingShingle | Ricardo E. Fretes Ulrike Kemmerling Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi Explants Journal of Tropical Medicine |
| title | Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi Explants |
| title_full | Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi Explants |
| title_fullStr | Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi Explants |
| title_full_unstemmed | Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi Explants |
| title_short | Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi Explants |
| title_sort | mechanism of trypanosoma cruzi placenta invasion and infection the use of human chorionic villi explants |
| url | http://dx.doi.org/10.1155/2012/614820 |
| work_keys_str_mv | AT ricardoefretes mechanismoftrypanosomacruziplacentainvasionandinfectiontheuseofhumanchorionicvilliexplants AT ulrikekemmerling mechanismoftrypanosomacruziplacentainvasionandinfectiontheuseofhumanchorionicvilliexplants |