Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age
Background: Limited data are available on vitamin A kinetics and total body stores (TBS) in women. Such information can be obtained using compartmental modeling and retinol isotope dilution (RID). Objectives: Objectives were to apply population-based (“super-subject”) modeling to determine retinol k...
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Elsevier
2024-11-01
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| Series: | Current Developments in Nutrition |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2475299124024181 |
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| author | Michael H Green Veronica Lopez-Teros Joanne Balmer Green Georg Lietz Sika M Kumordzie Anthony Oxley Ahmed D Fuseini K Winifred Nyaaba Emily Becher Jennie N Davis K Ryan Wessells Seth Adu-Afarwuah Reina Engle-Stone Marjorie J Haskell |
| author_facet | Michael H Green Veronica Lopez-Teros Joanne Balmer Green Georg Lietz Sika M Kumordzie Anthony Oxley Ahmed D Fuseini K Winifred Nyaaba Emily Becher Jennie N Davis K Ryan Wessells Seth Adu-Afarwuah Reina Engle-Stone Marjorie J Haskell |
| author_sort | Michael H Green |
| collection | DOAJ |
| description | Background: Limited data are available on vitamin A kinetics and total body stores (TBS) in women. Such information can be obtained using compartmental modeling and retinol isotope dilution (RID). Objectives: Objectives were to apply population-based (“super-subject”) modeling to determine retinol kinetics in nonpregnant Ghanaian women of reproductive age and to use RID to predict TBS in the group and its individuals. Methods: Women (n = 89) ingested a dose of [2H6]retinyl acetate and blood samples (3/woman) were collected from 6 h to 91 d, with all participants sampled at 14 d, about half at either 21 or 28 d, and each at one other time. Composite data (plasma retinol fraction of dose; FDp) were analyzed using Simulation, Analysis and Modeling software to obtain kinetic parameters, TBS, and other state variables as well as model-derived values for the RID composite coefficient FaS. The latter were used in the RID equation TBS (μmol) = FaS × 1/SAp (where SAp is plasma retinol specific activity) to predict TBS at various times. Results: Model-predicted TBS was 973 μmol (n = 87). Geometric mean RID-predicted TBS was 965, 926, and 1006 μmol at 14, 21, and 28 d, respectively, with wide ranges [for example, 252–3848 μmol on day 14 (n = 86)]; TBS predictions were similar at later times. Participants had a mean 2 y of vitamin A in stores and estimated liver vitamin A concentrations in the normal range. Model-predicted vitamin A disposal rate was 1.3 μmol/d and plasma recycling number was 37. Conclusions: Super-subject modeling provides an estimate of group mean TBS as well as group-specific values for the RID coefficient FaS; the latter can be used to confidently predict TBS by RID for individual participants in the group under study or in similar individuals at 14 d or more after isotope ingestion. Trial registration number: Trial is registered (NCT04632771) at https://clinicaltrials.gov. |
| format | Article |
| id | doaj-art-037a7da26567475780893a79f81ac8c0 |
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| language | English |
| publishDate | 2024-11-01 |
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| spelling | doaj-art-037a7da26567475780893a79f81ac8c02025-08-20T02:48:39ZengElsevierCurrent Developments in Nutrition2475-29912024-11-0181110448410.1016/j.cdnut.2024.104484Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive AgeMichael H Green0Veronica Lopez-Teros1Joanne Balmer Green2Georg Lietz3Sika M Kumordzie4Anthony Oxley5Ahmed D Fuseini6K Winifred Nyaaba7Emily Becher8Jennie N Davis9K Ryan Wessells10Seth Adu-Afarwuah11Reina Engle-Stone12Marjorie J Haskell13Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, United States; Corresponding author.Department of Chemical and Biological Sciences, Universidad de Sonora, Hermosillo, Sonora, MexicoDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA, United StatesHuman Nutrition Research Centre, Newcastle University, Newcastle Upon Tyne, United KingdomInstitute for Global Nutrition and Department of Nutrition, University of California, Davis, Davis, CA, United StatesHuman Nutrition Research Centre, Newcastle University, Newcastle Upon Tyne, United KingdomDepartment of Nutrition and Food Science, University of Ghana, Legon, Accra, GhanaDepartment of Nutrition and Food Science, University of Ghana, Legon, Accra, GhanaInstitute for Global Nutrition and Department of Nutrition, University of California, Davis, Davis, CA, United StatesInstitute for Global Nutrition and Department of Nutrition, University of California, Davis, Davis, CA, United StatesInstitute for Global Nutrition and Department of Nutrition, University of California, Davis, Davis, CA, United StatesDepartment of Nutrition and Food Science, University of Ghana, Legon, Accra, GhanaInstitute for Global Nutrition and Department of Nutrition, University of California, Davis, Davis, CA, United StatesInstitute for Global Nutrition and Department of Nutrition, University of California, Davis, Davis, CA, United States; Corresponding author.Background: Limited data are available on vitamin A kinetics and total body stores (TBS) in women. Such information can be obtained using compartmental modeling and retinol isotope dilution (RID). Objectives: Objectives were to apply population-based (“super-subject”) modeling to determine retinol kinetics in nonpregnant Ghanaian women of reproductive age and to use RID to predict TBS in the group and its individuals. Methods: Women (n = 89) ingested a dose of [2H6]retinyl acetate and blood samples (3/woman) were collected from 6 h to 91 d, with all participants sampled at 14 d, about half at either 21 or 28 d, and each at one other time. Composite data (plasma retinol fraction of dose; FDp) were analyzed using Simulation, Analysis and Modeling software to obtain kinetic parameters, TBS, and other state variables as well as model-derived values for the RID composite coefficient FaS. The latter were used in the RID equation TBS (μmol) = FaS × 1/SAp (where SAp is plasma retinol specific activity) to predict TBS at various times. Results: Model-predicted TBS was 973 μmol (n = 87). Geometric mean RID-predicted TBS was 965, 926, and 1006 μmol at 14, 21, and 28 d, respectively, with wide ranges [for example, 252–3848 μmol on day 14 (n = 86)]; TBS predictions were similar at later times. Participants had a mean 2 y of vitamin A in stores and estimated liver vitamin A concentrations in the normal range. Model-predicted vitamin A disposal rate was 1.3 μmol/d and plasma recycling number was 37. Conclusions: Super-subject modeling provides an estimate of group mean TBS as well as group-specific values for the RID coefficient FaS; the latter can be used to confidently predict TBS by RID for individual participants in the group under study or in similar individuals at 14 d or more after isotope ingestion. Trial registration number: Trial is registered (NCT04632771) at https://clinicaltrials.gov.http://www.sciencedirect.com/science/article/pii/S2475299124024181Ghanamodel-based compartmental analysisretinol isotope dilutionvitamin A statuswomen of reproductive age |
| spellingShingle | Michael H Green Veronica Lopez-Teros Joanne Balmer Green Georg Lietz Sika M Kumordzie Anthony Oxley Ahmed D Fuseini K Winifred Nyaaba Emily Becher Jennie N Davis K Ryan Wessells Seth Adu-Afarwuah Reina Engle-Stone Marjorie J Haskell Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age Current Developments in Nutrition Ghana model-based compartmental analysis retinol isotope dilution vitamin A status women of reproductive age |
| title | Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age |
| title_full | Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age |
| title_fullStr | Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age |
| title_full_unstemmed | Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age |
| title_short | Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age |
| title_sort | use of population based compartmental modeling and retinol isotope dilution to study vitamin a kinetics and total body stores among ghanaian women of reproductive age |
| topic | Ghana model-based compartmental analysis retinol isotope dilution vitamin A status women of reproductive age |
| url | http://www.sciencedirect.com/science/article/pii/S2475299124024181 |
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